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Patent Searching and Data


Title:
PROMYOSTATIN PEPTIDES AND METHODS OF USING SAME
Document Type and Number:
WIPO Patent Application WO2002009641
Kind Code:
A9
Abstract:
The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as a myostatin prodomain or a mature myostatin peptide, as well as functional peptide portions a moystatin prodomain a myostatin. Also provided is a mutant promyostatin polypeptide, which is resistant to proteolytic cleavage, for example, cleavage into a myostatin prodomain and a mature myostatin peptide. The present invention also provides a polynucleotide encoding a peptide portion of a promyostatin polypeptide. In addition, antibodies that specifically bind a peptide portion of a promyostatin polypeptide are provided. The invention further provides methods of identifying a functional peptide portion of a promyostatin polypeptide.

Inventors:
LEE SE-JIN
MCPHERRON ALEXANDRA C
Application Number:
PCT/US2001/023510
Publication Date:
March 20, 2003
Filing Date:
July 26, 2001
Export Citation:
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Assignee:
UNIV JOHNS HOPKINS MED (US)
International Classes:
A01K67/027; A23L13/00; A23L13/50; A23L15/00; C07K5/11; C07K14/46; C07K14/47; C07K14/475; C07K16/18; C12N15/09; G01N33/48; G01N33/53; G01N33/566; A61K38/00; (IPC1-7): C07K14/00; A61K38/00
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