Title:
PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR HEPATOCELLULAR CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2014/168191
Kind Code:
A1
Abstract:
Provided is a drug that is useful for preventing and/or treating hepatocellular carcinoma.
The drug for preventing and/or treating hepatocellular carcinoma comprises a combination of a non-cyclic retinoid, a salt thereof or a solvate of the same with an angiotensin II receptor blocker, a salt thereof or a solvate of the same.
Inventors:
YOSHIJI HITOSHI (JP)
FUKUI HIROSHI (JP)
FUKUI HIROSHI (JP)
Application Number:
PCT/JP2014/060359
Publication Date:
October 16, 2014
Filing Date:
April 10, 2014
Export Citation:
Assignee:
PUBLIC UNIVERSITY CORP NARA MEDICAL UNIVERSITY (JP)
KOWA CO (JP)
KOWA CO (JP)
International Classes:
A61K31/202; A61K31/41; A61K31/4178; A61K31/4184; A61K45/06; A61P1/16; A61P31/12; A61P35/00
Domestic Patent References:
| WO2012068531A2 | 2012-05-24 | |||
| WO2012020785A1 | 2012-02-16 |
Foreign References:
| JP2008537538A | 2008-09-18 | |||
| JP2009511570A | 2009-03-19 |
Other References:
HITOSHI YOSHIJI ET AL.: "Sorafenib to angiotensin-II Juyotai Sogaiyaku (ARB) Heiyo ni yoru Kan Hatsugan Yokusei", ACTA HEPATOLOGICA JAPONICA, vol. 53, no. SUPPL., 2012, pages A568
KOSUKE KAJI ET AL.: "Kan Byotai Shinten ni Okeru Sanka Stress to sono Seigyo: Keiko Tetsu Chelate Zai to Angiotensin II Juyotai Kikkoyaku ni yoru Shinki Chiryo no Kokoromi", ACTA HEPATOLOGICA JAPONICA, vol. 52, no. SUPPL., 2011, pages A258 - O-213
SHINJI TANAKA ET AL.: "Current status and perspective of antiangiogenic therapy for cancer: hepatocellular carcinoma", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 11, 2006, pages 82 - 89
MASAO HONDA ET AL.: "Hi-Kanshiki Retinoid Toyo ni Tomonau Kan Soshiki Idenshi Hatsugen Henka to Kan Sen'ika Hatsugan Yokusei Kiko", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 109, 2012, pages A76 - S4-1
HIKARI OKADA ET AL.: "Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development", CANCER RESEARCH, vol. 72, no. 17, 2012, pages 4459 - 4471
TOMOHIKO SAKABE ET AL.: "An antioxidant effect by acyclic retinoid suppresses liver tumor in mice", BIOCHEMICAL PHARMACOLOGY, vol. 73, 2007, pages 1405 - 1411
MASAHITO SHIMIZU ET AL.: "Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice", HEPATOLOGY RESEARCH, vol. 42, 2012, pages 1241 - 1247
KOSUKE KAJI ET AL.: "Kan Byotai Shinten ni Okeru Sanka Stress to sono Seigyo: Keiko Tetsu Chelate Zai to Angiotensin II Juyotai Kikkoyaku ni yoru Shinki Chiryo no Kokoromi", ACTA HEPATOLOGICA JAPONICA, vol. 52, no. SUPPL., 2011, pages A258 - O-213
SHINJI TANAKA ET AL.: "Current status and perspective of antiangiogenic therapy for cancer: hepatocellular carcinoma", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 11, 2006, pages 82 - 89
MASAO HONDA ET AL.: "Hi-Kanshiki Retinoid Toyo ni Tomonau Kan Soshiki Idenshi Hatsugen Henka to Kan Sen'ika Hatsugan Yokusei Kiko", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 109, 2012, pages A76 - S4-1
HIKARI OKADA ET AL.: "Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development", CANCER RESEARCH, vol. 72, no. 17, 2012, pages 4459 - 4471
TOMOHIKO SAKABE ET AL.: "An antioxidant effect by acyclic retinoid suppresses liver tumor in mice", BIOCHEMICAL PHARMACOLOGY, vol. 73, 2007, pages 1405 - 1411
MASAHITO SHIMIZU ET AL.: "Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice", HEPATOLOGY RESEARCH, vol. 42, 2012, pages 1241 - 1247
Attorney, Agent or Firm:
YUITA, Junji et al. (JP)
Junji Yuita (JP)
Junji Yuita (JP)
Download PDF: