PROPHYLACTIC AND THERAPEUTIC AGENT FOR SEPTICEMIA

Title:

PROPHYLACTIC AND THERAPEUTIC AGENT FOR SEPTICEMIA

Document Type and Number:

WIPO Patent Application WO/2015/147240

Kind Code:

A1

Abstract:

Provided is a prophylactic and therapeutic agent for septicemia, in particular septic shocks, said agent comprising as an active ingredient orexin, a highly active derivative of orexin or an orexin receptor agonist and being efficacious when administered peripherally.

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Inventors:

IRUKAYAMA YOKO (JP)
OGAWA YASUHIRO (JP)
YANAGISAWA MASASHI (JP)

Application Number:

PCT/JP2015/059548

Publication Date:

October 01, 2015

Filing Date:

March 27, 2015

Export Citation:

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Assignee:

UNIV TSUKUBA (JP)
UNIV TEXAS SOUTHWESTERN MED CT (US)

International Classes:

A61K38/00; A61K45/00; A61P7/10; A61P9/00; A61P11/00; A61P31/04; A61P43/00

Other References:

DEUTSCH MAN, C. S. ET AL.: "Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis", CRIT. CARE. MED., vol. 41, no. 11, 2013, pages e368 - 75
KASTIN, A. J. ET AL.: "Orexin A but not orexin B rapidly enters brain from blood by simple diffusion", J. PHARMACOL. EXP. THER., vol. 289, no. 1, 1999, pages 219 - 23, XP055225077

Attorney, Agent or Firm:

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

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