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Patent Searching and Data


Title:
PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/061720
Kind Code:
A3
Abstract:
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

Inventors:
MALININ VLADIMIR (US)
PERKINS WALTER (US)
LEIFER FRANZISKA (US)
KONICEK DONNA (US)
LI ZHILI (US)
PLAUNT ADAM (US)
Application Number:
PCT/US2014/062232
Publication Date:
June 11, 2015
Filing Date:
October 24, 2014
Export Citation:
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Assignee:
INSMED INC (US)
International Classes:
A01N37/00; A61K31/19; C07C62/00
Foreign References:
US20130261187A12013-10-03
US4837342A1989-06-06
Other References:
See also references of EP 3060041A4
Attorney, Agent or Firm:
TUSCAN, Michael et al. (1299 Pennsylvania Avenue N.W.,Suite 70, Washington District of Columbia, US)
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