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Patent Searching and Data


Title:
PROTEIN HETERODIMER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/221136
Kind Code:
A1
Abstract:
The present application provides a protein heterodimer and use thereof. The protein heterodimer comprises a first polypeptide chain and a second polypeptide chain different from the first polypeptide chain, wherein the first polypeptide chain comprises IL12a, and the second polypeptide chain comprises IL12b. The protein heterodimer also comprises IL2 or its functional fragments, GMCSF or its functional fragments, and one or more targeting moieties. The protein heterodimer can be used for the treatment of tumors.

Inventors:
ZHANG JINYU (CN)
Application Number:
PCT/CN2020/086755
Publication Date:
November 05, 2020
Filing Date:
April 24, 2020
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Assignee:
ZHANG JINYU (CN)
International Classes:
C07K19/00; A61K38/16; A61P35/00; C12N15/09
Foreign References:
CN1382158A2002-11-27
Other References:
QIAN WEN, ET AL.: "Fusion cytokine IL‑2‑GMCSF enhances anticancer immune responses through promoting cell–cell interactions", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 14, 31 January 2016 (2016-01-31), XP055382486, DOI: 20200605184832Y
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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