Title:
PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR FROM ANTARCTIC MARINE-DERIVED ASPERGILLUS SP. SF-5929
Document Type and Number:
WIPO Patent Application WO/2020/017864
Kind Code:
A1
Abstract:
The present invention pertains to: a novel diphenol derivative, (±)-tylopilusin D, derived from a marine-derived fungus Aspergillus sp.; and a composition for inhibiting protein tyrosine phosphatase 1B, the composition containing the (±)-tylopilusin D or a salt thereof as an active ingredient. The (±)-tylopilusin D according to the present invention effectively inhibits PTP1B activity, and can thus be used to treat PTP1B-related diseases such as cancer, diabetes, and obesity.
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Inventors:
YIM JOUNG HAN (KR)
OH HYUN CHEOL (KR)
SOHN JAE HAK (KR)
KIM DONG-CHEOL (KR)
TRAN MINH HA (VN)
OH HYUN CHEOL (KR)
SOHN JAE HAK (KR)
KIM DONG-CHEOL (KR)
TRAN MINH HA (VN)
Application Number:
PCT/KR2019/008764
Publication Date:
January 23, 2020
Filing Date:
July 16, 2019
Export Citation:
Assignee:
KOREA INST OCEAN SCI & TECH (KR)
International Classes:
C07C69/757; A61K31/215; A61K31/352; A61P29/00; A61P35/00; C07C49/753; C07D311/78
Foreign References:
| JPH03163017A | 1991-07-15 |
Other References:
FUKUDA, T. ET AL.: "Tylopilusins, diphenolic metabolites from the fruitingbodies of Tylopilus eximius", JOURNAL OF NATURAL PRODUCTS, vol. 75, no. 12, 2012, pages 2228 - 2231, XP055677558, DOI: 10.1021/np300428r
INOKOSHI, J. ET AL.: "Funalenone, a novel collagenase inhibitor produced by Aspergillus niger", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 12, 1999, pages 1095 - 1100, XP055677561
HUANG, H. -B. ET AL.: "Cytotoxic Naphtho-y-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E", HELVETICA CHIMICA ACTA, vol. 94, no. 9, 2011, pages 1732 - 1740, XP055677569, DOI: 10.1002/hlca.201100050
HAGIMORI, K. ET AL.: "Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 30, no. 8, 2007, pages 1379 - 1383, XP055677574
KIM, D. -C. ET AL.: "Protein tyrosine phosphatase 1B inhibitors from a marine-derived fungal strain aspergillus sp. SF-5929", NATURAL PRODUCT RESEARCH, vol. 34, no. 5, 16 November 2018 (2018-11-16), pages 675 - 682, XP055677578, DOI: 10.1080/14786419.2018.1499629
INOKOSHI, J. ET AL.: "Funalenone, a novel collagenase inhibitor produced by Aspergillus niger", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 12, 1999, pages 1095 - 1100, XP055677561
HUANG, H. -B. ET AL.: "Cytotoxic Naphtho-y-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E", HELVETICA CHIMICA ACTA, vol. 94, no. 9, 2011, pages 1732 - 1740, XP055677569, DOI: 10.1002/hlca.201100050
HAGIMORI, K. ET AL.: "Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 30, no. 8, 2007, pages 1379 - 1383, XP055677574
KIM, D. -C. ET AL.: "Protein tyrosine phosphatase 1B inhibitors from a marine-derived fungal strain aspergillus sp. SF-5929", NATURAL PRODUCT RESEARCH, vol. 34, no. 5, 16 November 2018 (2018-11-16), pages 675 - 682, XP055677578, DOI: 10.1080/14786419.2018.1499629
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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