Title:
PURIFIED CARDIOGENIN ISOMER AND RELATED METHODS
Document Type and Number:
WIPO Patent Application WO/2012/088264
Kind Code:
A3
Abstract:
A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC™ column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).
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Inventors:
KYAS ANDREAS (CH)
FREUND ERNST (CH)
SCHLOERKE OLIVER (CH)
PATERNITI JAMES R (US)
ELLIOTT GARY (US)
LILL JORG (CH)
ROGALL LARS (CH)
MENIA DARIO (CH)
FREUND ERNST (CH)
SCHLOERKE OLIVER (CH)
PATERNITI JAMES R (US)
ELLIOTT GARY (US)
LILL JORG (CH)
ROGALL LARS (CH)
MENIA DARIO (CH)
Application Number:
PCT/US2011/066469
Publication Date:
January 17, 2013
Filing Date:
December 21, 2011
Export Citation:
Assignee:
HUYA BIOSCIENCE INTERNAT LLC (US)
KYAS ANDREAS (CH)
FREUND ERNST (CH)
SCHLOERKE OLIVER (CH)
PATERNITI JAMES R (US)
ELLIOTT GARY (US)
LILL JORG (CH)
ROGALL LARS (CH)
MENIA DARIO (CH)
KYAS ANDREAS (CH)
FREUND ERNST (CH)
SCHLOERKE OLIVER (CH)
PATERNITI JAMES R (US)
ELLIOTT GARY (US)
LILL JORG (CH)
ROGALL LARS (CH)
MENIA DARIO (CH)
International Classes:
C07H15/24; A61K31/70; A61K36/73; C07J19/00
Domestic Patent References:
| WO2010143062A1 | 2010-12-16 |
Foreign References:
| US20090028959A1 | 2009-01-29 | |||
| US5916919A | 1999-06-29 | |||
| US20030118635A1 | 2003-06-26 |
Other References:
CHENG, L. ET AL.: "A Plant-Derived Remedy for Repair of Infarcted Heart", PLOS ONE, vol. 4, no. 2, February 2009 (2009-02-01), pages E4461, XP055112799
Attorney, Agent or Firm:
PRINCE, Robert et al. (Legal Department12531 High Bluff Drive, Suite 13, San Diego CA, US)
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