PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS

Title:

PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS

Document Type and Number:

WIPO Patent Application WO/2012/158811

Kind Code:

A3

Abstract:

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2'-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.

Inventors:

SCHINAZI RAYMOND F (US)
CHO JONG HYUN (US)
ZHOU LONGHU (US)
ZHANG HONGWANG (US)
PRADERE UGO (US)
COATS STEVEN J (US)

Application Number:

PCT/US2012/038165

Publication Date:

February 28, 2013

Filing Date:

May 16, 2012

Export Citation:

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Assignee:

RFS PHARMA LLC (US)
SCHINAZI RAYMOND F (US)
CHO JONG HYUN (US)
ZHOU LONGHU (US)
ZHANG HONGWANG (US)
PRADERE UGO (US)
COATS STEVEN J (US)
UNIV EMORY (US)

International Classes:

C07H19/20; A61K31/7028; A61K31/7072; A61K31/7076; A61P31/12; C07D405/04; C07D487/04; C07H19/10; C07H19/173

Domestic Patent References:

WO2010091386A2	2010-08-12
WO2006121820A1	2006-11-16
WO2008121634A2	2008-10-09
WO2007017248A2	2007-02-15
WO2001090121A2	2001-11-29

Foreign References:

US20100016251A1

2010-01-21

Other References: