Title:
PURINE NUCLEOSIDE DERIVATIVE, POLYNUCLEOTIDE AND RNA
Document Type and Number:
WIPO Patent Application WO/2018/047909
Kind Code:
A1
Abstract:
Disclosed is a purine nucleoside derivative represented by formula (Ia) or the like. In the formula, each of X1 and X2 independently represents a nitrogen atom, -CH= or -CR2= (wherein R2 represents an alkyl group); Ar represents an optionally substituted aryl group or an optionally substituted heteroaryl group; R1 represents a hydrogen atom or an optionally substituted alkyl group; and Z represents a sugar residue.
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Inventors:
OGASAWARA SHINJI (JP)
Application Number:
PCT/JP2017/032310
Publication Date:
March 15, 2018
Filing Date:
September 07, 2017
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07H19/207; C07H21/02; C12N15/09; C12N15/11; C12N15/113
Domestic Patent References:
| WO2014034934A1 | 2014-03-06 | |||
| WO2017066782A1 | 2017-04-20 |
Foreign References:
| JPH0959293A | 1997-03-04 | |||
| JP2008516938A | 2008-05-22 | |||
| JP2011207863A | 2011-10-20 | |||
| JP2009126789A | 2009-06-11 |
Other References:
LI,L. ET AL.: "Silica-based helical rod supporting guanosine compounds catalyzed asymmetric hetero-Diels-Alder reaction", CATALYSIS COMMUNICATIONS, vol. 64, 2015, pages 6 - 11, XP055497429
KUTTAPPAN-NAIR,V. ET AL.: "Generation of 2'- Deoxyadenosine N6-Aminyl Radicals from the Photolysis of Phenylhydrazone Derivatives", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 23, no. 1, 2010, pages 48 - 54, XP055497431
HATCHER,J.F. ET AL.: "Identification of N- (deoxyguanosin-8-yl)-4-azobiphenyl by 32P- postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4- aminobiphenyl", ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, vol. 39, no. 4, 2002, pages 314 - 322, XP055497432
BOEGE,N. ET AL.: "First route to phosphoramidites of N2-hydrazinoaryl- and N2-azoaryl-dG adducts and their site-selective incorporation into DNA oligonucleotides", SYNLETT, vol. 7, 2008, pages 1066 - 1070
WANNER,M.J. ET AL.: "Synthesis and properties of 2-nitrosoadenosine, Journal of the Chemical Society", PERKIN TRANSACTIONS, vol. 1, no. 16, 2001, pages 1908 - 1915, XP002386103
KATO,K. ET AL.: "A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 20, 1997, pages 6833 - 6841, XP002162654
WONG,C.G. ET AL.: "Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 4, 1984, pages 429 - 432, XP002038613
OGASAWARA,S. ET AL.: "Duration control of protein expression in vivo by light-mediated reversible activation of translation", ACS CHEMICAL BIOLOGY, vol. 12, no. 2, February 2017 (2017-02-01), pages 351 - 356, XP055497435
KUTTAPPAN-NAIR,V. ET AL.: "Generation of 2'- Deoxyadenosine N6-Aminyl Radicals from the Photolysis of Phenylhydrazone Derivatives", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 23, no. 1, 2010, pages 48 - 54, XP055497431
HATCHER,J.F. ET AL.: "Identification of N- (deoxyguanosin-8-yl)-4-azobiphenyl by 32P- postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4- aminobiphenyl", ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, vol. 39, no. 4, 2002, pages 314 - 322, XP055497432
BOEGE,N. ET AL.: "First route to phosphoramidites of N2-hydrazinoaryl- and N2-azoaryl-dG adducts and their site-selective incorporation into DNA oligonucleotides", SYNLETT, vol. 7, 2008, pages 1066 - 1070
WANNER,M.J. ET AL.: "Synthesis and properties of 2-nitrosoadenosine, Journal of the Chemical Society", PERKIN TRANSACTIONS, vol. 1, no. 16, 2001, pages 1908 - 1915, XP002386103
KATO,K. ET AL.: "A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 20, 1997, pages 6833 - 6841, XP002162654
WONG,C.G. ET AL.: "Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 4, 1984, pages 429 - 432, XP002038613
OGASAWARA,S. ET AL.: "Duration control of protein expression in vivo by light-mediated reversible activation of translation", ACS CHEMICAL BIOLOGY, vol. 12, no. 2, February 2017 (2017-02-01), pages 351 - 356, XP055497435
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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