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Patent Searching and Data


Title:
PYRAZINE DERIVATIVE OR SALT THEREOF, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2021/085582
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide a compound useful as an antitumor agent, etc., and a pharmaceutical composition, antitumor agent, and dihydroorotate dehydrogenase inhibitor that include the compound. The present invention provides a compound represented by general formula (1) or a salt thereof. In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; R2, R3, R4, and R5 are the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group, etc.; R6 are the same or different and represent a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; R7 represents an optionally substituted C3-8 cycloalkyl group, etc.; m represents an integer of 0-6; and a broken line represents a single bond or a double bond.

Inventors:
YAMAKAWA TAKAYUKI (JP)
TSUTSUI YASUHIRO (JP)
Application Number:
PCT/JP2020/040744
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
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Assignee:
FUJIFILM CORP (JP)
International Classes:
A61P35/00; A61K31/4965; A61K31/497; A61P43/00; C07D241/28; C07D405/12
Domestic Patent References:
WO2018157843A12018-09-07
WO2016044666A12016-03-24
WO2014069510A12014-05-08
WO2014069510A12014-05-08
WO2019043407A12019-03-07
WO2017221008A12017-12-28
Foreign References:
JP2010513362A2010-04-30
US20110306589A12011-12-15
Other References:
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, pages: 696 - 926
RICHARD C. LAROCK ET AL.: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, pages: 823 - 827
BENJAMIN BADERWOLFGANG KNECHTMARKUS FRIESMONIKA LOFFLER: "Expression, Purification, and Characterization of Histidine-Tagged Rat and Human Flavoenzyme Dihydroorotate Dehydrogenase", PROTEIN EXPRESSION AND PURIFICATION, vol. 13, 1998, pages 414 - 422, XP004445222, DOI: 10.1006/prep.1998.0925
See also references of EP 4052760A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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