Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PYRAZOLE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/019958
Kind Code:
A1
Abstract:
A compound represented by the general formula (I) (wherein R1 is H, optionally substituted C1-6 alkyl, etc.; either of Q and T is the group of the formula (II) or the formula (III) and the other is optionally substituted C1-6 alkyl or cycloalkyl; R2 is H, halogeno, OH, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxy, etc.; R3, R5, and R6 each is H, halogeno, C1-6 alkyl, etc.; and R4 is H, OH, optionally substituted amino, etc.), a pharmacologically acceptable salt of the compound, and a prodrug of either. They have excellent human SGLT1 inhibitory activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia such as diabetes, impaired glucose tolerance, fasting blood sugar abnormality, complications of diabetes, and obesity and for diseases attributable to an increased blood galactose level such as galactosemia.

Inventors:
FUSHIMI NOBUHIKO (JP)
TERANISHI HIROTAKA (JP)
SHIOHARA HIROAKI (JP)
SHIMIZU KAZUO (JP)
YONEKUBO SHIGERU (JP)
ITO FUMIAKI (JP)
ISAJI MASAYUKI (JP)
Application Number:
PCT/JP2003/010550
Publication Date:
March 11, 2004
Filing Date:
August 21, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KISSEI PHARMACEUTICAL (JP)
FUSHIMI NOBUHIKO (JP)
TERANISHI HIROTAKA (JP)
SHIOHARA HIROAKI (JP)
SHIMIZU KAZUO (JP)
YONEKUBO SHIGERU (JP)
ITO FUMIAKI (JP)
ISAJI MASAYUKI (JP)
International Classes:
A61K31/10; A61K31/205; A61K31/37; A61K31/4166; A61K31/7056; A61K31/7072; A61K31/737; A61P3/04; A61P3/06; A61P3/10; A61P5/48; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07H17/02; (IPC1-7): A61K31/7056; C07H17/02; A61K31/10; A61K31/205; A61K31/37; A61K31/4166; A61K31/7072; A61K31/737; A61K38/00; A61K38/26; A61K38/27; A61K38/28; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P5/48; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00
Domestic Patent References:
WO2002036602A12002-05-10
WO2002053573A12002-07-11
WO2002098893A12002-12-12
Foreign References:
EP1213296A12002-06-12
Other References:
DYER JANE ET AL.: "Sugar analogues as potential inhibitors of the intestinal Na+/glucose co-transporter(SGLT1)", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 26, no. 2, 1998, pages S180, XP002973976
Download PDF: