Title:
PYRAZOLOPYRIDINONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/101183
Kind Code:
A1
Abstract:
Pyrazolopyridinone compounds, the pharmaceutical compositions comprising said compounds, and the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and their use in the treatment of diseases, e.g. cancer.
Inventors:
GUO HAIBING (CN)
WAN ZHAO-KUI (CN)
QIN LUOHENG (CN)
LIU QIAN (CN)
CHEUNG WING SHUN (CN)
WAN ZHAO-KUI (CN)
QIN LUOHENG (CN)
LIU QIAN (CN)
CHEUNG WING SHUN (CN)
Application Number:
PCT/CN2018/117296
Publication Date:
May 31, 2019
Filing Date:
November 23, 2018
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P35/00; C07D519/00
Domestic Patent References:
| WO2002018383A2 | 2002-03-07 | |||
| WO2004018419A2 | 2004-03-04 | |||
| WO2002018383A2 | 2002-03-07 | |||
| WO2002022598A1 | 2002-03-21 | |||
| WO2003087095A1 | 2003-10-23 | |||
| WO2004018419A2 | 2004-03-04 | |||
| WO2004043389A2 | 2004-05-27 | |||
| WO2005046589A2 | 2005-05-26 | |||
| WO2012018909A1 | 2012-02-09 |
Foreign References:
| US4666828A | 1987-05-19 | |||
| US4683202A | 1987-07-28 | |||
| US4801531A | 1989-01-31 | |||
| US5192659A | 1993-03-09 | |||
| US5272057A | 1993-12-21 | |||
| US5882864A | 1999-03-16 | |||
| US6218529B1 | 2001-04-17 | |||
| US5221683A | 1993-06-22 |
Other References:
FRAZIER, K. ET AL.: "Design and structure-activity relationship of heterocyclic analogs of 4- amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 16, no. 8, 30 January 2006 (2006-01-30), pages 2247 - 2251, XP025106948, ISSN: 0960-894X, DOI: doi:10.1016/j.bmcl.2006.01.020
JERRY MARCH: "Advanced Organic Chemistry", 1992, WILEY INTERSCIENCE, pages: 109 - 114
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY
BERGE ET AL.: "Pharmaceutically Acceptable Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
CAHNINGOLDPRELOG, ANGEW. CHEM. INT. ED. ENGL., vol. 5, 1966, pages 385 - 415
"Current Protocols in Molecular Biology", 2004, JOHN WILEY & SONS INC.
"PCR Protocols: a guide to methods and applications", 1990, ACADEMIC PRESS
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
ORREROGERS, INT J CANCER, vol. 84, no. 2, 1999, pages 101 - 8
ACSMEDICINAL CHEMISTRY LETTERS, 2013, pages 979
JOURNAL OF MEDICINAL CHEMISTRY, 1993, pages 331
See also references of EP 3717483A4
JERRY MARCH: "Advanced Organic Chemistry", 1992, WILEY INTERSCIENCE, pages: 109 - 114
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY
BERGE ET AL.: "Pharmaceutically Acceptable Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
CAHNINGOLDPRELOG, ANGEW. CHEM. INT. ED. ENGL., vol. 5, 1966, pages 385 - 415
"Current Protocols in Molecular Biology", 2004, JOHN WILEY & SONS INC.
"PCR Protocols: a guide to methods and applications", 1990, ACADEMIC PRESS
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
ORREROGERS, INT J CANCER, vol. 84, no. 2, 1999, pages 101 - 8
ACSMEDICINAL CHEMISTRY LETTERS, 2013, pages 979
JOURNAL OF MEDICINAL CHEMISTRY, 1993, pages 331
See also references of EP 3717483A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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