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Title:
PYRAZOLYL 5-THIOGLUCOSIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/129668
Kind Code:
A1
Abstract:
Disclosed is a novel pyrazolyl 5-thio-β-D-glucopyranoside compound which can inhibit the SGLT1 activity selectively and can prevent the absorption of glucose through the digestive tract, thereby controlling the IGT (impaired glucose tolerance). Specifically, disclosed is a pyrazolyl 5-thioglucoside compound represented by the formula (I), a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt. [Chemical formula] wherein Z represents a C1-6 alkyl group; R1, R2 and R3 independently represent a hydrogen atom, a halogen atom, a C1-6 alkoxy group or a C1-6alkyl group; Y represents a single bond, a C1-6 alkylene group, a C2-6 alkenylene group or –O-(CH2)n- [wherein n represents an integer ranging from 1 to 4]; and Q represents a hydroxyl group, -OC1-4-alkylphenyl, -N(RA)RB or –CONHRC.

Inventors:
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
Application Number:
PCT/JP2007/059386
Publication Date:
November 15, 2007
Filing Date:
May 02, 2007
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
International Classes:
C07H17/02; A61K31/7056; A61P3/10; A61P43/00
Domestic Patent References:
WO2004014932A12004-02-19
WO2004019958A12004-03-11
WO2004018491A12004-03-04
WO2004031203A12004-04-15
Foreign References:
EP1609799A12005-12-28
JP2006117651A2006-05-11
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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