Title:
PYRAZOLYL 5-THIOGLUCOSIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2007/129668
Kind Code:
A1
Abstract:
Disclosed is a novel pyrazolyl 5-thio-β-D-glucopyranoside compound which can inhibit the SGLT1 activity selectively and can prevent the absorption of glucose through the digestive tract, thereby controlling the IGT (impaired glucose tolerance). Specifically, disclosed is a pyrazolyl 5-thioglucoside compound represented by the formula (I), a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt. [Chemical formula] wherein Z represents a C1-6 alkyl group; R1, R2 and R3 independently represent a hydrogen atom, a halogen atom, a C1-6 alkoxy group or a C1-6alkyl group; Y represents a single bond, a C1-6 alkylene group, a C2-6 alkenylene group or –O-(CH2)n- [wherein n represents an integer ranging from 1 to 4]; and Q represents a hydroxyl group, -OC1-4-alkylphenyl, -N(RA)RB or –CONHRC.
Inventors:
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
Application Number:
PCT/JP2007/059386
Publication Date:
November 15, 2007
Filing Date:
May 02, 2007
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
KAKINUMA HIROYUKI (JP)
KOBASHI YOHEI (JP)
TAKAHASHI HITOMI (JP)
OI TAKAHIRO (JP)
HASHIMOTO YUKO (JP)
International Classes:
C07H17/02; A61K31/7056; A61P3/10; A61P43/00
Domestic Patent References:
WO2004014932A1 | 2004-02-19 | |||
WO2004019958A1 | 2004-03-11 | |||
WO2004018491A1 | 2004-03-04 | |||
WO2004031203A1 | 2004-04-15 |
Foreign References:
EP1609799A1 | 2005-12-28 | |||
JP2006117651A | 2006-05-11 |
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
Download PDF: