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Title:
PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2019/178305
Kind Code:
A8
Abstract:
The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1 ) and boronates of Formula (2), stereoisomers thereof; wherein Q is selected from the group consisting of -P(0)(OH)2, -P(0)(OH)(0"M+), - P(0)(0"M+)2 and -P(0)(0")2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Inventors:
BROWN MATTHEW (US)
CHE YE (US)
MARFAT ANTHONY (US)
MELNICK MICHAEL (US)
MONTGOMERY JUSTIN (US)
JOHNSON TIMOTHY (US)
EWIN RICHARD (US)
UCCELLO DANIEL (US)
REILLY USA (US)
BRAISH TAMIM (US)
Application Number:
PCT/US2019/022170
Publication Date:
October 29, 2020
Filing Date:
March 14, 2019
Export Citation:
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Assignee:
PFIZER (US)
International Classes:
A61K31/6615; A61K31/69; A61P31/04; C07D249/06; C07D405/12; C07F5/04; C07F9/09
Attorney, Agent or Firm:
SULLIVAN, Kelly, M. et al. (US)
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