Title:
PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166974
Kind Code:
A1
Abstract:
A pyridopyrimidinone derivative as represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof or a prodrug thereof. The pyridopyrimidinone derivative has a good SOS1 inhibitory effect.
More Like This:
Inventors:
ZHANG XUEJUN (CN)
CHANG SHAOHUA (CN)
LI XUEQIANG (CN)
YE DABING (CN)
WANG HONGQIANG (CN)
SUN HONGNA (CN)
YANG JUN (CN)
LI LI'E (CN)
CHANG SHAOHUA (CN)
LI XUEQIANG (CN)
YE DABING (CN)
WANG HONGQIANG (CN)
SUN HONGNA (CN)
YANG JUN (CN)
LI LI'E (CN)
Application Number:
PCT/CN2022/075428
Publication Date:
August 11, 2022
Filing Date:
February 08, 2022
Export Citation:
Assignee:
WUHAN HUMANWELL INNOVATIVE DRUG RES AND DEVELOPMENT CENTER LIMITED COMPANY (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/00; A61P35/02; C07D453/02; C07D519/00
Domestic Patent References:
WO2020221209A1 | 2020-11-05 | |||
WO2016186888A1 | 2016-11-24 | |||
WO2019122129A1 | 2019-06-27 |
Foreign References:
CN113200981A | 2021-08-03 | |||
CN101687797A | 2010-03-31 | |||
CN104169281A | 2014-11-26 | |||
CN111372932A | 2020-07-03 | |||
CN110167928A | 2019-08-23 | |||
CN202110172372A | 2021-02-08 | |||
CN202111315868A | 2021-11-08 |
Other References:
DATABASE REGISTRY 18 April 2017 (2017-04-18), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2091635-76-4 REGISTRY ED -Entered STN: 18 Apr 2017 CN -Sulfur, [4-(1-aminoethyl)-2-fluorophenyl]pentafluoro-, (OC-6-21)- (CA INDEX NAME)", XP055957750, retrieved from STN Database accession no. 2091635-76-4
HUNTER ET AL., MOL. CANCER RES., vol. 13, no. 9, 2015, pages 1325 - 1335
HOBBS GA ET AL., J CELL SCI., vol. 129, no. 7, 2016, pages 1287 - 1292
COX, ADRIENNE D. ET AL., NAT REV DRUG DISCOV., vol. 13, no. 11, 2014, pages 828 - 851
LIU P ET AL., ACTA PHARM SIN B., vol. 9, no. 5, 2019, pages 871 - 879
PIERRE S ET AL., BIOCHEM PHARMACOL., vol. 82, no. 9, 2011, pages 1049 - 1056
HILLIG, ROMAN C. ET AL., PROC NAT ACAD SCI USA, vol. 116, no. 7, 2019, pages 2551 - 2560
HOFMANN, MARCO H ET AL., CANCER DISCOV., 2020
BOEHRINGER INGELHEIM, AACR ANNUAL MEETING, 27 April 2020 (2020-04-27)
JOSE M ROJAS ET AL., GENES CANCER, vol. 2, no. 3, 2011, pages 298 - 305
NARUMI, YOKO ET AL., J HUM GENET., vol. 53, no. 9, 2008, pages 834 - 841
JANG SI ET AL., J BIOL CHEM., vol. 282, no. 28, 2007, pages 20245 - 20255
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
MAEHR, J. CHEM. ED., vol. 62, 1985, pages 114 - 120
HUNTER ET AL., MOL. CANCER RES., vol. 13, no. 9, 2015, pages 1325 - 1335
HOBBS GA ET AL., J CELL SCI., vol. 129, no. 7, 2016, pages 1287 - 1292
COX, ADRIENNE D. ET AL., NAT REV DRUG DISCOV., vol. 13, no. 11, 2014, pages 828 - 851
LIU P ET AL., ACTA PHARM SIN B., vol. 9, no. 5, 2019, pages 871 - 879
PIERRE S ET AL., BIOCHEM PHARMACOL., vol. 82, no. 9, 2011, pages 1049 - 1056
HILLIG, ROMAN C. ET AL., PROC NAT ACAD SCI USA, vol. 116, no. 7, 2019, pages 2551 - 2560
HOFMANN, MARCO H ET AL., CANCER DISCOV., 2020
BOEHRINGER INGELHEIM, AACR ANNUAL MEETING, 27 April 2020 (2020-04-27)
JOSE M ROJAS ET AL., GENES CANCER, vol. 2, no. 3, 2011, pages 298 - 305
NARUMI, YOKO ET AL., J HUM GENET., vol. 53, no. 9, 2008, pages 834 - 841
JANG SI ET AL., J BIOL CHEM., vol. 282, no. 28, 2007, pages 20245 - 20255
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
MAEHR, J. CHEM. ED., vol. 62, 1985, pages 114 - 120
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: