Title:
PYRIMIDINE CARBOXAMIDE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/127909
Kind Code:
A1
Abstract:
A pyrimidine carboxamide compound as shown in formula I, or a tautomer, mesomer, racemate, enantiomer and diastereomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, which can be used as a Vanin enzyme inhibitor, and can be used to prepare a medicament for treating various conditions, including Crohn's disease and ulcerative colitis.
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Inventors:
YAO YUANSHAN (CN)
LUAN LINBO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
LUAN LINBO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2021/139172
Publication Date:
June 23, 2022
Filing Date:
December 17, 2021
Export Citation:
Assignee:
SHANGHAI MEIYUE BIOTECH DEV CO LTD (CN)
International Classes:
A61K31/506; C07D239/42; A61P29/00; C07D403/12
Domestic Patent References:
| WO2020123426A1 | 2020-06-18 | |||
| WO2016193844A1 | 2016-12-08 |
Foreign References:
| CN109476645A | 2019-03-15 | |||
| CN102378757A | 2012-03-14 | |||
| CN202011499721A | 2020-12-17 | |||
| CN202111521781A | 2021-12-13 | |||
| CN109476645A | 2019-03-15 |
Other References:
BERRUYER C ET AL.: "Vanin-I-/- mice exhibit a glutathione mediated tissue resistance to oxidative stress", MOL. CELL BIOL., vol. 24, 2004, pages 7214 - 7224
BERRUYER C ET AL.: "Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor 7 activity", J. EXP. MED., vol. 203, 2006, pages 2817 - 2827, XP002687503, DOI: 10.1084/JEM.20061640
ROMMELAERE S: "PPARalpha regulates the production of serum Vanin-1 by liver.", FEBS LETT., vol. 587, no. 22, 15 November 2013 (2013-11-15), pages 3742 - 8, XP028766011, DOI: 10.1016/j.febslet.2013.09.046
U.S. FOOD AND DRUG ADMINISTRATION: "Inactive Ingredient Guide", 1996
ASHASH: "Hand book of Pharmaceutical Additives", 2002, SYNAPSE INFORMATION RESOURCES, INC.
"Handbook of Chemistry and Physics", 1994
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
BERRUYER C ET AL.: "Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor 7 activity", J. EXP. MED., vol. 203, 2006, pages 2817 - 2827, XP002687503, DOI: 10.1084/JEM.20061640
ROMMELAERE S: "PPARalpha regulates the production of serum Vanin-1 by liver.", FEBS LETT., vol. 587, no. 22, 15 November 2013 (2013-11-15), pages 3742 - 8, XP028766011, DOI: 10.1016/j.febslet.2013.09.046
U.S. FOOD AND DRUG ADMINISTRATION: "Inactive Ingredient Guide", 1996
ASHASH: "Hand book of Pharmaceutical Additives", 2002, SYNAPSE INFORMATION RESOURCES, INC.
"Handbook of Chemistry and Physics", 1994
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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