Title:
PYRROLIDINE MODULATORS OF CCR5 CHEMOKINE RECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO2002034716
Kind Code:
A3
Abstract:
Pyrrolidine compounds of Formula (I), (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6a>, R<6b>, R<7> and R<8> are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Inventors:
HALE JEFFREY J (US)
LYNCH CHRISTOPHER L (US)
CALDWELL CHARLES G (US)
WILLOUGHBY CHRISTOPHER A (US)
KIM DOOSEOP (US)
SHEN DONG-MING (US)
MILLS SANDER G (US)
CHAPMAN KEVIN T (US)
CHEN LIYA (US)
GENTRY AMY (US)
MACCOSS MALCOLM (US)
LYNCH CHRISTOPHER L (US)
CALDWELL CHARLES G (US)
WILLOUGHBY CHRISTOPHER A (US)
KIM DOOSEOP (US)
SHEN DONG-MING (US)
MILLS SANDER G (US)
CHAPMAN KEVIN T (US)
CHEN LIYA (US)
GENTRY AMY (US)
MACCOSS MALCOLM (US)
Application Number:
PCT/US2001/042562
Publication Date:
August 08, 2002
Filing Date:
October 09, 2001
Export Citation:
Assignee:
MERCK & CO INC (US)
HALE JEFFREY J (US)
LYNCH CHRISTOPHER L (US)
CALDWELL CHARLES G (US)
WILLOUGHBY CHRISTOPHER A (US)
KIM DOOSEOP (US)
SHEN DONG-MING (US)
MILLS SANDER G (US)
CHAPMAN KEVIN T (US)
CHEN LIYA (US)
GENTRY AMY (US)
MACCOSS MALCOLM (US)
HALE JEFFREY J (US)
LYNCH CHRISTOPHER L (US)
CALDWELL CHARLES G (US)
WILLOUGHBY CHRISTOPHER A (US)
KIM DOOSEOP (US)
SHEN DONG-MING (US)
MILLS SANDER G (US)
CHAPMAN KEVIN T (US)
CHEN LIYA (US)
GENTRY AMY (US)
MACCOSS MALCOLM (US)
International Classes:
A61K31/4162; A61K31/454; A61K31/4545; A61P1/04; A61P3/10; A61P7/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; C07D487/04; A61P19/00; A61P19/02; A61P19/08; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P29/00; A61P31/18; A61P33/10; A61P33/12; A61P33/14; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D471/04; C07D491/052; C07D495/04; (IPC1-7): A61K31/675; A61K31/495; A61K31/50; A61K31/445; A61K31/44; A61K31/40; C07F9/02; C07F9/06; C07F9/28; C07F9/547; C07D209/44; C07D209/52; C07D401/00; C07D403/00
Foreign References:
| US6248755B1 | 2001-06-19 |
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