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Patent Searching and Data


Title:
QUATERNARY AMMONIUM SALT COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/156359
Kind Code:
A1
Abstract:
Disclosed in the present invention are a quaternary ammonium salt compound and a preparation method therefor and a use thereof, relating to the field of medicinal chemistry. Disclosed in the present invention is the compound shown in formula I, and a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a solvate thereof, a prodrug thereof, or a metabolite thereof. The compound is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound shown in formula I of the present invention and the pharmaceutically acceptable salt thereof can be used for the preparation of safe drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect, having the advantages of a long local anaesthetic effect time, good local anaesthetic selectivity, and high safety.

Inventors:
KE BOWEN (CN)
LIU JIN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
TANG LEI (CN)
Application Number:
PCT/CN2020/073387
Publication Date:
August 06, 2020
Filing Date:
January 21, 2020
Export Citation:
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Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07D211/60; A61K31/167; A61P23/02; C07C237/00; C07D205/04; C07D207/16; C07D223/06
Foreign References:
CN110156665A2019-08-23
CN1295558A2001-05-16
CN103601650A2014-02-26
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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