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Patent Searching and Data


Title:
RADIOISOTOPE LABELED COMPOUND FOR IMAGING OR TREATMENT OF PROSTATE CANCER
Document Type and Number:
WIPO Patent Application WO/2021/080352
Kind Code:
A1
Abstract:
The present invention relates to: a derivative in which glutamate-urea-Lysine (GUL) and isonitril are linked by a linker; a radioisotope labeled compound comprising the derivative; and a pharmaceutical composition for treating and diagnosing prostate cancer, containing the derivative as an active ingredient. A derivative according to the present invention has high binding capacity for PSMA, which is expressed in prostate cancer, by acting as a multi-ligand through the binding of three or six derivatives to one atom of technetium or rhenium, has excellent stability in human serum when administered in vivo, and is excreted into the kidney rather than the hepatobiliary tract because of high water solubility so that a clear image of a prostate cancer tumor site can be obtained, and thus the present invention can be effectively usable as a pharmaceutical composition for treating or diagnosing prostate cancer.

Inventors:
JEONG JAE MIN (KR)
LODHI NADEEM AHMED (KR)
LEE YUN-SANG (KR)
Application Number:
PCT/KR2020/014501
Publication Date:
April 29, 2021
Filing Date:
October 22, 2020
Export Citation:
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Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07C275/24; A61K47/02; A61K47/22; A61K51/04; A61P35/00; C07F1/08
Domestic Patent References:
WO2018215627A12018-11-29
WO2009002529A22008-12-31
WO2016040179A12016-03-17
Foreign References:
KR20190114908A2019-10-10
Other References:
LODHI N. A.: "Synthesis and In Vivo Biological Evaluation of 99mTc (I) Tri-carbonyl Based Radiopharmaceuticals for SPECT Imaging", PH.D. THESIS, SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE, 1 January 2019 (2019-01-01), XP055804170, Retrieved from the Internet
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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