RAPID RESOLUTION PROCESS FOR CLOPIDOGREL BASE AND A PROCESS FOR PREPARATION OF CLOPIDOGREL BISULFATE POLYMORPH - FORM I

Title:

RAPID RESOLUTION PROCESS FOR CLOPIDOGREL BASE AND A PROCESS FOR PREPARATION OF CLOPIDOGREL BISULFATE POLYMORPH - FORM I

Document Type and Number:

WIPO Patent Application WO2006087729

Kind Code:

B1

Abstract:

The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.

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Inventors:

TARUR VENKATASUBRAMANIAN RADHA (IN)
SATHE DHANANJAY GOVIND (IN)
SAWANT KAMLESH DIGAMBAR (IN)
MONDKAR HARISH KASHINATH (IN)
DESHPANDE MANOJ MADHUKARRAO (IN)
NAIK TUSHAR ANIL (IN)

Application Number:

PCT/IN2005/000048

Publication Date:

November 09, 2006

Filing Date:

February 15, 2005

Export Citation:

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Assignee:

USV LTD (IN)

International Classes:

C07D495/04

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