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Title:
RECOMBINANT C-REACTIVE PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/106453
Kind Code:
A1
Abstract:
The present invention improves the accuracy of a latex reagent-based immunoassay in a CRP high concentration range. Provided is a C-reactive protein produced by genetic recombination, wherein 55% or more of the N-termini of the C-reactive protein are pyro-glutamylated.

Inventors:
MISHIMA AYAKA (JP)
SUMIDA YOSUKE (JP)
Application Number:
PCT/JP2020/039893
Publication Date:
June 03, 2021
Filing Date:
October 23, 2020
Export Citation:
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Assignee:
TOYO BOSEKI (JP)
International Classes:
C07K14/47; C12N15/12; C12N15/31; G01N33/53; G01N33/543; G01N33/96
Domestic Patent References:
WO2011155358A12011-12-15
Foreign References:
JPH06311884A1994-11-08
JP2000014388A2000-01-18
JP2018535394A2018-11-29
JP2006300758A2006-11-02
JPH08233816A1996-09-13
JP2011257243A2011-12-22
Other References:
E. B. OLIVEIRA, E. C. GOTSCHLICH, T. Y. LIU: "Primary structure of human C-reactive protein.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 74, no. 8, 1 August 1977 (1977-08-01), US, pages 3148 - 3151, XP055325302, ISSN: 0027-8424, DOI: 10.1073/pnas.74.8.3148
XIA DONG YUAN, YAO REN JIE, ZHANG LONG XIANG: "Primary Structure of Anodonta C-reactive Protein", CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 16, no. 2, 30 November 1999 (1999-11-30), pages 215 - 223, XP009529336, ISSN: 1007-7626
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