Title:
REFINING METHOD FOR AMINO ACID OR DERIVATIVES THEREOF, AND AMINO ACID OR DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/082859
Kind Code:
A1
Abstract:
Provided is a refining method for an amino acid or derivatives thereof, comprising: (1) preparing a saturated aqueous solution of an amino acid or derivatives thereof from a crude product of the amino acid or derivatives thereof at preset temperature; (2) performing first programmed cooling on the saturated aqueous solution to a metastable zone, adding seed crystals with the degree of sphericity not lower than 0.6, cultivating crystals at constant temperature to obtain a crystal slurry; and (3) performing second programmed cooling on the crystal slurry to second temperature, the rate of the second programmed cooling being no more than 1.0°C/min, and cultivating crystals at constant temperature to obtain the amino acid or derivatives thereof.
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Inventors:
ZHU CHENGJUN (CN)
SHU MIN (CN)
LI YUN (CN)
HUANG LEI (CN)
TANG PENG (CN)
LI JIANHUA (CN)
SU HAIXIA (CN)
ZHA LIYAN (CN)
GUO LIPING (CN)
LIU MENGJIE (CN)
HE JIAJUN (CN)
YANG LEI (CN)
LIU SHA (CN)
LV FANLIN (CN)
MEI XUECHEN (CN)
LIU ZHEN (CN)
SHU MIN (CN)
LI YUN (CN)
HUANG LEI (CN)
TANG PENG (CN)
LI JIANHUA (CN)
SU HAIXIA (CN)
ZHA LIYAN (CN)
GUO LIPING (CN)
LIU MENGJIE (CN)
HE JIAJUN (CN)
YANG LEI (CN)
LIU SHA (CN)
LV FANLIN (CN)
MEI XUECHEN (CN)
LIU ZHEN (CN)
Application Number:
PCT/CN2020/125919
Publication Date:
April 28, 2022
Filing Date:
November 02, 2020
Export Citation:
Assignee:
WUHAN GRAND HOYO CO LTD (CN)
International Classes:
C07C323/59; C07C229/08; C07C229/24; C07C279/14
Foreign References:
| CN104844488A | 2015-08-19 | |||
| CN106748849A | 2017-05-31 | |||
| CN102358720A | 2012-02-22 | |||
| CN104844488A | 2015-08-19 |
Other References:
CHADWICK K., DAVEY R. J., MUGHAL R., MARZIANO I.: "Crystallisation from Water-in-Oil Emulsions As a Route to Spherical Particulates: Glycine and the Hydrochloride Salts of Glutamic Acid and Ephedrine", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 6, 20 November 2009 (2009-11-20), US , pages 1284 - 1290, XP055924072, ISSN: 1083-6160, DOI: 10.1021/op900123n
TOLDY ARPAD I., ZHENG LU, BADRUDDOZA ABU ZAYED MD., HATTON T. ALAN, KHAN SAIF A.: "Dynamics and Morphological Outcomes in Thin-Film Spherical Crystallization of Glycine from Microfluidic Emulsions: Experimental Studies and Modeling", CRYSTAL GROWTH & DESIGN, ASC WASHINGTON DC, US, vol. 14, no. 7, 2 July 2014 (2014-07-02), US , pages 3485 - 3492, XP055924076, ISSN: 1528-7483, DOI: 10.1021/cg5004337
PRLIC KARDUM J., HRKOVAC M., LESKOVAC M.: "Adjustment of Process Conditions in Seeded Batch Cooling Crystallization", CHEMICAL ENGINEERING & TECHNOLOGY, J. WILEY, vol. 36, no. 8, 1 August 2013 (2013-08-01), pages 1347 - 1354, XP055797537, ISSN: 0930-7516, DOI: 10.1002/ceat.201300221
CRYSENGCOMM, vol. 15, 2013, pages 6498 - 6505
CRYSTENGCOMM, vol. 15, 2013, pages 6498 - 6505
TOLDY ARPAD I., ZHENG LU, BADRUDDOZA ABU ZAYED MD., HATTON T. ALAN, KHAN SAIF A.: "Dynamics and Morphological Outcomes in Thin-Film Spherical Crystallization of Glycine from Microfluidic Emulsions: Experimental Studies and Modeling", CRYSTAL GROWTH & DESIGN, ASC WASHINGTON DC, US, vol. 14, no. 7, 2 July 2014 (2014-07-02), US , pages 3485 - 3492, XP055924076, ISSN: 1528-7483, DOI: 10.1021/cg5004337
PRLIC KARDUM J., HRKOVAC M., LESKOVAC M.: "Adjustment of Process Conditions in Seeded Batch Cooling Crystallization", CHEMICAL ENGINEERING & TECHNOLOGY, J. WILEY, vol. 36, no. 8, 1 August 2013 (2013-08-01), pages 1347 - 1354, XP055797537, ISSN: 0930-7516, DOI: 10.1002/ceat.201300221
CRYSENGCOMM, vol. 15, 2013, pages 6498 - 6505
CRYSTENGCOMM, vol. 15, 2013, pages 6498 - 6505
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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