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Title:
REGULATION OF CSR SYSTEM FOR PRODUCTION OF LYSINE AND LYSINE-DERIVED PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2019/136585
Kind Code:
A1
Abstract:
Provided in the disclosure relates to microorganisms genetically modified to overexpress biofilm dispersal related polypeptides to enhance the production of lysine and lysine derivatives by the microorganism, method of generating such microorganism, and methods of producing lysine and lysine derivatives using the genetically modified microorganisms.

Inventors:
CHOU HOWARD (CN)
CHEN LING (CN)
LEI YUNFENG (CN)
LIU XIUCAI (CN)
Application Number:
PCT/CN2018/071859
Publication Date:
July 18, 2019
Filing Date:
January 09, 2018
Export Citation:
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Assignee:
CATHAY R & D CENTER CO LTD (CN)
CIBT AMERICA INC (US)
International Classes:
C12N15/00; C12N15/09; C12P13/00; C12P13/08
Domestic Patent References:
WO2003046184A12003-06-05
WO2007119574A22007-10-25
Foreign References:
EP2050816A12009-04-22
CN104388371A2015-03-04
Other References:
YAKANDAWALA, N. ET AL.: "Metabolic engineering of Escherichia coli to enhance phenylalanine production", APPL. MICROBIOL BIOTECHNOL, vol. 78, no. 2, 15 December 2007 (2007-12-15), pages 283 - 291, XP019586284
LU LIJUN; ZHUGE BIN; ZONG HONG; LU XINYAO; FANG HUIYING; SONG JIAN: "Improved production of L-tryptophan in Escherichia coli with csrB and tktA overexpression", CHINESE JOURNAL OF APPLIED & ENVIRONMENTAL BIOLOGY, vol. 21, no. 4, 25 August 2015 (2015-08-25), pages 647 - 651, XP055722213, ISSN: 1006-687X, DOI: 10.3724/SP.J.1145.2015.02023
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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