Title:
REMEDAL OR PREVENTIVE AGENT FOR CONGESTIVE HEART FAILURE
Document Type and Number:
WIPO Patent Application WO/2000/015213
Kind Code:
A1
Abstract:
A remedial or preventive agent for congestive heart failure which contains a compound represented by general formula (I), an optically active isomer, prodrug, or pharmacologically acceptable salt of the compound, or a hydrate of these. In formula (I), R?1¿ and R?2¿ each represents hydrogen, optionally substituted lower alkyl, optionally substituted (hetero)aryl, etc.; R?3¿ represents optionally substituted (hetero)arylene, etc.; R?4¿ represents, e.g., a single bond, -C$m(Z)C-, or a group represented by formula (i), R?5¿ represents optionally substituted (hetero)aryl, optionally substituted nonaromatic heterocyclic group, etc.; and Y represents NHOH or OH.
Inventors:
WATANABE FUMIHIKO (JP)
GEMBA TAKEFUMI (JP)
TSUZUKI HIROSHIGE (JP)
SHIMAMURA TOSHITAKE (JP)
GEMBA TAKEFUMI (JP)
TSUZUKI HIROSHIGE (JP)
SHIMAMURA TOSHITAKE (JP)
Application Number:
PCT/JP1999/004859
Publication Date:
March 23, 2000
Filing Date:
September 08, 1999
Export Citation:
Assignee:
SHIONOGI & CO (JP)
WATANABE FUMIHIKO (JP)
GEMBA TAKEFUMI (JP)
TSUZUKI HIROSHIGE (JP)
SHIMAMURA TOSHITAKE (JP)
WATANABE FUMIHIKO (JP)
GEMBA TAKEFUMI (JP)
TSUZUKI HIROSHIGE (JP)
SHIMAMURA TOSHITAKE (JP)
International Classes:
A61K31/18; A61K31/381; A61K31/4025; A61K31/41; A61K31/5377; (IPC1-7): A61K31/16; A61K31/165; A61K31/17; A61K31/195; A61K31/34; A61K31/38; A61K31/405; A61K31/41; A61K31/42; A61K31/425; A61K31/44; A61K31/535
Domestic Patent References:
| WO1998025597A2 | 1998-06-18 | |||
| WO1997027174A1 | 1997-07-31 | |||
| WO1998016503A2 | 1998-04-23 | |||
| WO1998009957A1 | 1998-03-12 | |||
| WO1998009934A1 | 1998-03-12 | |||
| WO1997019068A1 | 1997-05-29 | |||
| WO1999004780A1 | 1999-02-04 |
Foreign References:
| JPH11246527A | 1999-09-14 |
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Patent Dept. 12-4 Sagisu 5-chome Fukushima-ku, Osaka-shi Osaka, JP)
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