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Patent Searching and Data


Title:
RET INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/057963
Kind Code:
A1
Abstract:
Provided are an RET inhibitor, a pharmaceutical composition comprising same and a use thereof. Specifically, the present invention relates to a compound as shown in formula (I) or a stereoisomer, geometrical isomer, tautomer, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound as shown in formula (I), and further relates to a pharmaceutical composition comprising the compound, and a use of the compound and the pharmaceutical composition comprising same in the preparation of a drug, which drug is particularly used for treating and preventing diseases and conditions associated with RET, including cancers, irritable bowel syndrome and/or pain associated with irritable bowel syndrome.

Inventors:
XIE HONGMING (CN)
LUO MING (CN)
ZHANG YINGJUN (CN)
YANG GUIZHEN (CN)
WANG KAI (CN)
JIA YUANYUAN (CN)
Application Number:
PCT/CN2020/118065
Publication Date:
April 01, 2021
Filing Date:
September 27, 2020
Export Citation:
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Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/438; A61K31/439; A61K31/444; A61K31/454; A61K31/496; A61K31/4995; A61P1/00; A61P29/00; A61P35/00; C07D519/00
Domestic Patent References:
WO2020114487A12020-06-11
WO2020114494A12020-06-11
WO2020064009A12020-04-02
WO2018071447A12018-04-19
Foreign References:
CN108349969A2018-07-31
CN110267960A2019-09-20
CN110177786A2019-08-27
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