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Title:
RET SELECTIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/008455
Kind Code:
A1
Abstract:
Provided are an RET selective inhibitor, a preparation method therefor and a use thereof. Provided are a compound of formula (I) and a pharmaceutically acceptable salt, a solvent, a polymorph or an isomer thereof, a pharmaceutical composition containing the compounds, and the use of such compounds in the treatment of RET-related diseases.

Inventors:
LIU ZHIHUA (CN)
YUAN DECHUANG (CN)
CHEN KUNCHENG (CN)
YUAN BAOKUN (CN)
REN REN (CN)
MIN WANGYANG (CN)
LIU XIJIE (CN)
ZHANG KAI (CN)
SUN YONGLIANG (CN)
LU CHANG (CN)
SUN YINGHUI (CN)
Application Number:
CN2020/101338
Publication Date:
January 21, 2021
Filing Date:
July 10, 2020
Export Citation:
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Assignee:
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
International Classes:
C07D471/04; A61K31/496; A61K31/497; A61K31/4995; A61K31/55; A61P35/00; C07D519/00
Domestic Patent References:
WO2019075108A12019-04-18
WO2018136661A12018-07-26
WO2019075114A12019-04-18
Foreign References:
CN111285886A2020-06-16
CN108349969A2018-07-31
US20180133200A12018-05-17
Other References:
"2068064-80-0", STN REGISTRY, 8 February 2017 (2017-02-08), DOI: 20200901122556X
"2068064-78-6", STN REGISTRY, 8 February 2017 (2017-02-08), DOI: 20200901122549X
"2068064-76-4", STN REGISTRY, 8 February 2017 (2017-02-08), DOI: 20200901122556X
"2068064-66-2", STN REGISTRY, 8 February 2017 (2017-02-08), DOI: 20200901122641X
"2068061-77-6", STN REGISTRY, 8 February 2017 (2017-02-08), DOI: 20200901122659X
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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