Title:
RING-FUSED PYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/039961
Kind Code:
A1
Abstract:
Provided are a ring-fused pyrazole derivative, which is useful as a therapeutic agent and/or a preventive agent for diseases associated with Nav1. 1 and various central nervous system diseases, and/or a pharmaceutically acceptable salt thereof, and a pharmaceutical comprising the same as an active ingredient. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof. [In the formula: Y1, Y2 and Y3 independently represent N or CR2; R1 is a hydrogen atom, etc.; R2 is a hydrogen atom, etc.; M1 is a saturated or partially unsaturated C4-12 carbocyclic group, etc.; M2 is a group represented by formula (2a) or (2b), etc.; and X1a, X1b, X1c, X2, X3, X4, X5, X6, X7, X8, A1 and A2 are as stated in the description.]
Inventors:
NAKAI YOSHIO (JP)
IWAMOTO KOHEI (JP)
IWATA MASATO (JP)
SHIBATA HAJIME (JP)
SHIRO TOMOYA (JP)
FUKAZAWA RYO (JP)
IWAMOTO KOHEI (JP)
IWATA MASATO (JP)
SHIBATA HAJIME (JP)
SHIRO TOMOYA (JP)
FUKAZAWA RYO (JP)
Application Number:
PCT/JP2020/032589
Publication Date:
March 04, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K31/437; A61K31/4545; A61K31/496; A61K31/4985; A61K31/501; A61K31/502; A61K31/5025; A61K31/517; A61K31/519; A61K31/5377; A61P3/12; A61P25/00; A61P25/08; A61P25/14; A61P25/18; A61P43/00; C07D401/12; C07D471/04; C07D487/04; C07D519/00
Domestic Patent References:
WO2008147822A1 | 2008-12-04 | |||
WO2018098499A1 | 2018-05-31 |
Foreign References:
JP2006508036A | 2006-03-09 | |||
JP2016169161A | 2016-09-23 |
Other References:
DATABASE Registry [online] 25 December 2008 (2008-12-25), XP055797168, retrieved from STN Database accession no. 938522-45-3
CHAWA, K. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 5393 - 5395
FATHY, U. ET AL.: "Ultrasonic assisted synthesis, anticancer and antioxidant activity of some novel pyrazolo[3,4-b]pyridine derivatives", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 9, 2015, pages 4 - 12, XP055797165
CHAWA, K. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 5393 - 5395
FATHY, U. ET AL.: "Ultrasonic assisted synthesis, anticancer and antioxidant activity of some novel pyrazolo[3,4-b]pyridine derivatives", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 9, 2015, pages 4 - 12, XP055797165
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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