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Title:
RING-FUSED PYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/039961
Kind Code:
A1
Abstract:
Provided are a ring-fused pyrazole derivative, which is useful as a therapeutic agent and/or a preventive agent for diseases associated with Nav1. 1 and various central nervous system diseases, and/or a pharmaceutically acceptable salt thereof, and a pharmaceutical comprising the same as an active ingredient. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof. [In the formula: Y1, Y2 and Y3 independently represent N or CR2; R1 is a hydrogen atom, etc.; R2 is a hydrogen atom, etc.; M1 is a saturated or partially unsaturated C4-12 carbocyclic group, etc.; M2 is a group represented by formula (2a) or (2b), etc.; and X1a, X1b, X1c, X2, X3, X4, X5, X6, X7, X8, A1 and A2 are as stated in the description.]

Inventors:
NAKAI YOSHIO (JP)
IWAMOTO KOHEI (JP)
IWATA MASATO (JP)
SHIBATA HAJIME (JP)
SHIRO TOMOYA (JP)
FUKAZAWA RYO (JP)
Application Number:
PCT/JP2020/032589
Publication Date:
March 04, 2021
Filing Date:
August 28, 2020
Export Citation:
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Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K31/437; A61K31/4545; A61K31/496; A61K31/4985; A61K31/501; A61K31/502; A61K31/5025; A61K31/517; A61K31/519; A61K31/5377; A61P3/12; A61P25/00; A61P25/08; A61P25/14; A61P25/18; A61P43/00; C07D401/12; C07D471/04; C07D487/04; C07D519/00
Domestic Patent References:
WO2008147822A12008-12-04
WO2018098499A12018-05-31
Foreign References:
JP2006508036A2006-03-09
JP2016169161A2016-09-23
Other References:
DATABASE Registry [online] 25 December 2008 (2008-12-25), XP055797168, retrieved from STN Database accession no. 938522-45-3
CHAWA, K. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 5393 - 5395
FATHY, U. ET AL.: "Ultrasonic assisted synthesis, anticancer and antioxidant activity of some novel pyrazolo[3,4-b]pyridine derivatives", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 9, 2015, pages 4 - 12, XP055797165
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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