RNA APTAMER SPECIFICALLY BINDING TO PPARγ PROTEIN AND USE OF RNA APTAMER

WIPO Patent Application WO/2021/085920

A1

The present invention relates to an RNA aptamer that specifically binds to a PPARγ protein and to a use of the RNA aptamer. Specifically, the RNA aptamer according to the present invention strongly binds specifically to the PPARγ protein to inhibit fat differentiation, inhibits the expression of genes and proteins related to fat differentiation, and has the same effect in animal models fed on a high fat diet and thus can be useful in the treatment of obesity as well as for detecting PPARγ protein and for diagnosing obesity.

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JP2021525508	Compositions and Methods of Adjustable Co-Coupling Polypeptide Nanoparticle Delivery Systems for Nucleic Acid Therapeutics

KIM YANG HOON (KR)
SHIN WOO RI (KR)

PCT/KR2020/014376

May 06, 2021

October 21, 2020

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NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)

C12N15/115; A23L33/10; A61K31/7088; A61P3/04; G01N33/68

KR101793411B1	2017-11-03
KR20090100503A	2009-09-24
US6033656A	2000-03-07
KR20150058108A	2015-05-28

DATABASE Protein 24 May 2021 (2021-05-24), ANONYMOUS: "peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens]", XP055807149, retrieved from NCBI Database accession no. NP_056953

WETHEPEOPLE IP & LAW FIRM (KR)

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