Title:
RNA-MEDIATED INTERFERENCE TO CONTROL DISEASE IN TERRESTRIAL AND AQUACULTURE ANIMALS
Document Type and Number:
WIPO Patent Application WO2005079236
Kind Code:
A3
Abstract:
The invention is directed to compositions (e.g., feeds, feed supplements, and therapeutic products) and methods for inhibiting an animal pathogen using RNA-interference technology.
Inventors:
KYLE DAVID J (US)
DHAR ARUN K (US)
DHAR ARUN K (US)
Application Number:
PCT/US2005/003715
Publication Date:
March 16, 2006
Filing Date:
February 04, 2005
Export Citation:
Assignee:
ADVANCED BIONUTRITION CORP (US)
KYLE DAVID J (US)
DHAR ARUN K (US)
KYLE DAVID J (US)
DHAR ARUN K (US)
International Classes:
C12N15/11; C12N15/113; (IPC1-7): C07H27/04; A61K48/00
Other References:
ROSAS M.F. ET AL: "Stable expression of antisense RNAs targeted to the 5' non-coding region confers heterotypic inhibition to food and mouth desease virus infection.", J GENERAL VIROLOGY., vol. 84, 2003, pages 393 - 402, XP002992327
STURINO J.M. ET AL: "Expression of antisense RNA targeted against Streptococcus thermophilus Bacteriophages.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 68, no. 2, February 2002 (2002-02-01), pages 588 - 596, XP002992328
DE BACKER M.D. ET AL: "An antisense based functional genomics approach for identification of genes critical for growth of Canadian albicans.", NATURE BIOTECHNOLOGY., vol. 19, March 2001 (2001-03-01), pages 235 - 241, XP002276432
HAMMOND S.M. ET AL: "Post transcriptional gene silencing by double-stranded RNA.", NATURE., vol. 2, February 2001 (2001-02-01), pages 110 - 119, XP001146153
UZBEKOVA S. ET AL: "Transgenic rainbow trout expressed sGnRH antisense RNA under the control of sGnRH promoter of Atlantic salmon.", J OF MOLECULAR ENDOCRINOLOGY., vol. 25, 2000, pages 337 - 350, XP002992329
CHEN J. ET AL: "Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan DNA nanoparticles.", WORLD JOURNAL OF GASTROENTEROLOGY., vol. 10, no. 1, January 2004 (2004-01-01), pages 112 - 116, XP002992330
FIRE A. ET AL: "Potent and specific genetic interference by double-stranded RNAi C. elegans.", NATURE., vol. 391, February 1998 (1998-02-01), pages 806 - 811, XP002095876
STURINO J.M. ET AL: "Expression of antisense RNA targeted against Streptococcus thermophilus Bacteriophages.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 68, no. 2, February 2002 (2002-02-01), pages 588 - 596, XP002992328
DE BACKER M.D. ET AL: "An antisense based functional genomics approach for identification of genes critical for growth of Canadian albicans.", NATURE BIOTECHNOLOGY., vol. 19, March 2001 (2001-03-01), pages 235 - 241, XP002276432
HAMMOND S.M. ET AL: "Post transcriptional gene silencing by double-stranded RNA.", NATURE., vol. 2, February 2001 (2001-02-01), pages 110 - 119, XP001146153
UZBEKOVA S. ET AL: "Transgenic rainbow trout expressed sGnRH antisense RNA under the control of sGnRH promoter of Atlantic salmon.", J OF MOLECULAR ENDOCRINOLOGY., vol. 25, 2000, pages 337 - 350, XP002992329
CHEN J. ET AL: "Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan DNA nanoparticles.", WORLD JOURNAL OF GASTROENTEROLOGY., vol. 10, no. 1, January 2004 (2004-01-01), pages 112 - 116, XP002992330
FIRE A. ET AL: "Potent and specific genetic interference by double-stranded RNAi C. elegans.", NATURE., vol. 391, February 1998 (1998-02-01), pages 806 - 811, XP002095876
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