Title:
ROCK INHIBITOR-DICHLOROACETIC ACID COMPOUND SALT AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177292
Kind Code:
A1
Abstract:
Provided are a ROCK inhibitor-dichloroacetic acid compound salt or pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing the compounds and pharmaceutical application thereof, in particular to the application in preparation of a medicament for preventing and/or treating cardiovascular and cerebrovascular diseases such as pulmonary arterial hypertension, cerebral ischemic stroke, subarachnoid hemorrhage or the like.
Inventors:
HUANG ZHANGJIAN (CN)
ZHANG YIHUA (CN)
KONG HUI (CN)
PANG TAO (CN)
XIE WEIPING (CN)
WANG HONG (CN)
WU JIANBING (CN)
ZHANG YIHUA (CN)
KONG HUI (CN)
PANG TAO (CN)
XIE WEIPING (CN)
WANG HONG (CN)
WU JIANBING (CN)
Application Number:
PCT/CN2019/104913
Publication Date:
September 10, 2020
Filing Date:
September 09, 2019
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D401/12; A61K31/472; A61K31/551; A61P9/10; A61P9/12; A61P25/00; C07C51/41; C07C53/16; C07D217/02
Domestic Patent References:
| WO2018159700A1 | 2018-09-07 |
Foreign References:
| CN101092413A | 2007-12-26 | |||
| CN107106571A | 2017-08-29 | |||
| CN109734701A | 2019-05-10 |
Other References:
YAN, ZIMENG: "Dichloroacetate—a New Drug in Development", WORLD PHARMACY, vol. 18, no. 4, 31 December 1997 (1997-12-31), CN, pages 202 - 206, XP055731814, ISSN: 1672-9188
Attorney, Agent or Firm:
NANJING ZONGHENG INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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