Title:
ROPIVACAINE HYDROCHLORIDE IMPURITY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/032936
Kind Code:
A1
Abstract:
The present invention provides a ropivacaine hydrochloride impurity and a preparation method therefor. The structural formula of the ropivacaine hydrochloride impurity is as shown in formula I. The ropivacaine hydrochloride impurity of the present invention is a new compound discovered by an inventor in the research process. The ropivacaine hydrochloride impurity has important significance in quality control in the ropivacaine hydrochloride synthesis process, and the inventor finds that the ropivacaine hydrochloride impurity with the structural formula as shown in formula I has excellent anesthetic performance through research and can be used for a new anesthetic drug. The method is simple to operate, the condition is mild, the reaction generation of the ropivacaine hydrochloride impurity is realized only by mixing the reaction raw materials, and no temperature control is required. The preparation method is low in cost without side reaction, the ropivacaine hydrochloride impurity prepared through the reaction has high purity and yield, and it facilitates reducing the quality control analysis cost of ropivacaine hydrochloride.
Inventors:
CHEN HAILONG (CN)
KE HAIMEI (CN)
LIU WENJUN (CN)
LI YANFEI (CN)
JU YUNFENG (CN)
TAN MINQING (CN)
KE HAIMEI (CN)
LIU WENJUN (CN)
LI YANFEI (CN)
JU YUNFENG (CN)
TAN MINQING (CN)
Application Number:
PCT/CN2020/133210
Publication Date:
February 17, 2022
Filing Date:
December 02, 2020
Export Citation:
Assignee:
GUANGDONG JIABO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D211/60
Foreign References:
| CN111925317A | 2020-11-13 | |||
| CN109053623A | 2018-12-21 |
Other References:
LIU MING, WU QIANGSAN, HU WENXIANG: "Pharmacophore Screening on Piperidinecarboxamides Derivatives Based on GALAHAD and CoMFA Models", CHINESE JOURNAL OF CHEMISTRY, vol. 29, no. 6, 1 June 2011 (2011-06-01), CN , pages 1075 - 1083, XP055901276, ISSN: 1001-604X, DOI: 10.1002/cjoc.201190204
BIN HO, PRABHA M. VENKATARANGAN, SHARON F. CRUSE ET AL.: "Synthesis of 2-piperidinecarboxylic acid derivatives as potential anticonvulsants", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1 January 1998 (1998-01-01), AMSTERDAM, NL , pages 23 - 31, XP002348704, ISSN: 0223-5234, DOI: 10.1016/S0223-5234(99)80072-5
BIN HO, PRABHA M. VENKATARANGAN, SHARON F. CRUSE ET AL.: "Synthesis of 2-piperidinecarboxylic acid derivatives as potential anticonvulsants", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1 January 1998 (1998-01-01), AMSTERDAM, NL , pages 23 - 31, XP002348704, ISSN: 0223-5234, DOI: 10.1016/S0223-5234(99)80072-5
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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