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Patent Searching and Data


Title:
RSK INHIBITORS AND THERAPEUTIC USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003105766
Kind Code:
A3
Abstract:
The present invention is directed to novel compounds and compositions that have Rsk specific inhibitory activity. In addition, inhibition of Rsk by the present compounds has been discovered to halt the proliferation of cancer cell lines while having little effect on the proliferation rate of normal cells. Therefore, the present invention identifies Rsk as a target for therapeutic intervention in diseased states in which the disease or the symptoms can be ameliorated by inhibition of Rsk catalytic activity.

Inventors:
SMITH JEFFREY A (US)
LANNIGAN-MACARA DEBORAH A (US)
POTEET-SMITH CELESTE E (US)
HECHT SIDNEY M (US)
XU YAMING (US)
BRAUTIGAN DAVID L (US)
Application Number:
PCT/US2003/018734
Publication Date:
March 11, 2004
Filing Date:
June 12, 2003
Export Citation:
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Assignee:
UNIV VIRGINIA (US)
SMITH JEFFREY A (US)
LANNIGAN-MACARA DEBORAH A (US)
POTEET-SMITH CELESTE E (US)
HECHT SIDNEY M (US)
XU YAMING (US)
BRAUTIGAN DAVID L (US)
International Classes:
C07H17/07; (IPC1-7): C07H17/00
Domestic Patent References:
WO2000066721A22000-11-09
Other References:
See also references of EP 1539781A4
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