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Patent Searching and Data


Title:
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/098117
Kind Code:
A8
Abstract:
The invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Inventors:
CHARISSE KLAUS (US)
NAIR JAYAPRAKASH (US)
SCHLEGEL MARK (US)
JANAS MAJA (US)
JADHAV VASANT (US)
FOSTER DONALD (US)
MANOHARAN MUTHIAH (US)
RAJEEV KALLANTHOTTATHIL (US)
KEL'IN ALEXANDER (US)
MAIER MARTIN (US)
MATSUDA SHIGEO (US)
JAYARAMAN MUTHUSAMY (US)
SEHGAL ALFICA (US)
BROWN CHRISTOPHER (US)
FITZGERALD KEVIN (US)
MILSTEIN STUART (US)
Application Number:
PCT/US2017/062701
Publication Date:
May 14, 2021
Filing Date:
November 21, 2017
Export Citation:
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Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
International Classes:
C12N15/87; C12N15/113
Attorney, Agent or Firm:
ZACHARAKIS, Maria Laccotripe et al. (US)
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