Title:
β SECRETASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2007/029587
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (1) below which is useful as
a drug for treating Alzheimer's disease, or a pharmaceutically acceptable
salt thereof. (1) [In the formula, R1 represents a group represented
by the following formula (2): (2) (wherein X represents a nitrogen atom or a group
expressed as C(R5); Y represents a nitrogen atom or a group expressed
as C(R6); and R5 and R6 independently represent
a hydrogen atom or the like) or the like; m represents an integer of 1-6; L1
represents a single bond or the like; R2 represents a hydrogen atom,
a substituted or unsubstituted alkyl group or the like; R3 represents
a hydrogen atom or the like; L2 represents a single bond or the like;
and R4 represents a hydrogen atom, a substituted or unsubstituted
aryl group or the like.]
Inventors:
KISO YOSHIAKI (JP)
MIMOTO TSUTOMU (JP)
NOJIMA SATOSHI (JP)
KINOMURA NAOYA (JP)
MIMOTO TSUTOMU (JP)
NOJIMA SATOSHI (JP)
KINOMURA NAOYA (JP)
Application Number:
PCT/JP2006/317178
Publication Date:
March 15, 2007
Filing Date:
August 31, 2006
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
KISO YOSHIAKI (JP)
MIMOTO TSUTOMU (JP)
NOJIMA SATOSHI (JP)
KINOMURA NAOYA (JP)
KISO YOSHIAKI (JP)
MIMOTO TSUTOMU (JP)
NOJIMA SATOSHI (JP)
KINOMURA NAOYA (JP)
International Classes:
C07C279/22; A61K31/41; A61K31/4168; A61K31/454; A61K31/506; A61P25/28; A61P43/00; C07D233/88; C07D235/30; C07D257/06; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12
Domestic Patent References:
| WO2005040126A1 | 2005-05-06 | |||
| WO2004050609A1 | 2004-06-17 | |||
| WO2004080376A2 | 2004-09-23 | |||
| WO2006036664A1 | 2006-04-06 | |||
| WO2001000665A2 | 2001-01-04 | |||
| WO2004043916A1 | 2004-05-27 | |||
| WO2004080376A2 | 2004-09-23 | |||
| WO2004076478A1 | 2004-09-10 |
Foreign References:
| JPS5690050A | 1981-07-21 | |||
| JPH0228144A | 1990-01-30 |
Other References:
See also references of EP 1942101A4
NATURE, vol. 402, 1999, pages 537 - 540
J. AM. CHEM. SOC., vol. 122, 2000, pages 3522 - 3523
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 1527 - 1531
BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 211 - 215
SCHRCDER; LUHKE: "The Peptides", vol. 1, 1966, ACADEMIC PRESS
NOBUO IZUMIYA ET AL., BASIS AND EXPERIMENT OF PEPTIDE SYNTHESIS, 1985
GREEN: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS
R. NISHIZAWA ET AL., J. MED. CHEM., vol. 20, 1977, pages 510
W. YUAN ET AL., J. MED. CHEM., vol. 36, 1993, pages 211
T. L. LITTLE ET AL., J. ORG. CHEM., vol. 59, 1994, pages 7299 - 7305
R. SAMUEL ET AL., J. ORG. CHEM., vol. 73, 1951, pages 602
NATURE, vol. 402, 1999, pages 537 - 540
J. AM. CHEM. SOC., vol. 122, 2000, pages 3522 - 3523
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 1527 - 1531
BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 211 - 215
SCHRCDER; LUHKE: "The Peptides", vol. 1, 1966, ACADEMIC PRESS
NOBUO IZUMIYA ET AL., BASIS AND EXPERIMENT OF PEPTIDE SYNTHESIS, 1985
GREEN: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS
R. NISHIZAWA ET AL., J. MED. CHEM., vol. 20, 1977, pages 510
W. YUAN ET AL., J. MED. CHEM., vol. 36, 1993, pages 211
T. L. LITTLE ET AL., J. ORG. CHEM., vol. 59, 1994, pages 7299 - 7305
R. SAMUEL ET AL., J. ORG. CHEM., vol. 73, 1951, pages 602
Attorney, Agent or Firm:
ISOBE, Yutaka (Dainippon Sumitomo Pharma Co. Ltd., 1-98, Kasugadenaka 3-chome, Konohana-k, Osaka-shi Osaka 22, JP)
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