Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
SELF-ASSEMBLED THIN FILM COATING TO ENHANCE THE BIOCOMPATIBILITY OF MATERIALS
Document Type and Number:
WIPO Patent Application WO2001078906
Kind Code:
A9
Abstract:
We make a subtrate biocompatible by contacting it with a starting material and initiating alternating charge layer electrostatic self-assembly to form a thin film. Starting materials may be poly(vinylpyrrolidone), poly{bis-(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l)-lysine, poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long-sidechain fullerene, or other polymers that participate in electrostatic self-assembly. The thin film fabrication advantageously may be at room temperature. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device. The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically self-assembled from at least a polymer or fullerene asmentioned. The substrate is not particulary limited, and may be quartz, glass, plastic, metal or ceramic, a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a catheter, a stent or other substrates.

Inventors:
SPILLMAN WILLIAM B JR (US)
WANG YOU-XIONG (US)
CLAUS RICHARD O (US)
Application Number:
PCT/US2001/012042
Publication Date:
December 27, 2002
Filing Date:
April 13, 2001
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
VIRGINIA TECH INTELL PROP (US)
SPILLMAN WILLIAM B JR (US)
WANG YOU-XIONG (US)
CLAUS RICHARD O (US)
International Classes:
A61N1/36; A61F2/84; A61L15/00; A61L27/00; A61L27/34; A61L29/00; A61L31/10; A61M1/14; A61M5/14; A61M25/00; B05B5/08; B05C3/09; B05D1/04; B05D1/18; (IPC1-7): B05D1/04
Download PDF: