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Title:
SENOLYTIC PRODRUGS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/056270
Kind Code:
A1
Abstract:
Senolytic prodrugs are provided, which are designed from a cytotoxic agent, by chemically modifying the cytotoxic agent to incorporate a site cleavable by SA-β-gal following delivery of the prodrug in vivo, to release the active parent drug. The prodrug includes a galactose-based moiety, which is preferably acetylated, and benzyl oxy carboxy group and a cytotoxic agent moiety. The selenolytic prodrug is used to selectively kill one or more senescent cells in a subject in need thereof, by administering to the subject therapeutically effective amount of the senolytic prodrugs. The disclosed compositions can be used to reduce one or more symptoms associated with a Senescence-associated disease or disorder in a subject.

Inventors:
DENG HONGKUI (CN)
LUO TUOPING (CN)
CAI YUSHENG (CN)
ZHOU HUANHUAN (CN)
ZHU YINHUA (CN)
Application Number:
PCT/CN2019/107887
Publication Date:
April 01, 2021
Filing Date:
September 25, 2019
Export Citation:
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Assignee:
UNIV BEIJING (CN)
International Classes:
C07H15/26; A61K31/7068; A61P29/00; A61P39/00; C07H19/073
Domestic Patent References:
WO2017189553A12017-11-02
WO2009016647A12009-02-05
Foreign References:
US5561119A1996-10-01
US20180094015A12018-04-05
Other References:
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SHARMA AMIT; KIM EUN-JOONG; SHI HU; LEE JIN YONG; CHUNG BONG GEUN; KIM JONG SEUNG: "Development of a theranostic prodrug for colon cancer therapy by combining ligand-targeted delivery and enzyme-stimulated activation.", BIOMATERIALS, vol. 155, 20 November 2017 (2017-11-20), pages 145 - 151, XP085320144, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.11.019
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Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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