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Title:
SIALIC CARBOHYDRATES
Document Type and Number:
WIPO Patent Application WO2003064439
Kind Code:
A3
Abstract:
The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and in the prevention and treatment of infections in humans and animals. In said formula (II), Sia represents a sialic acid or a sialic acid derivative in an alpha 2-3 bond, Gal represents a galactose-monosaccharide-unit, HexNac represents an N-acetylated galactosamine or glucosamine-monosaccharide-unit (GalNAc or G1cNAc), Hex represents a galactose- or glucose-monosaccharide-unit (Ga1 or G1c), C represents HexNac or Hex or is absent, n represents 1 - 50, V represents OH, a carbohydrate radical or a connecting point on a support T, with the proviso that if V represents OH, n represents 1, and if V represents a carbohydrate radical or a support T, n represents the number of carbohydrate unites of general formula (II) directly connected to said carbohydrate radical or support, X represents a sialic acid or a sialic acid derivative, wherein a second sialic acid or a sialic acid derivative or more sialic acid or sialic acid derivatives can be connected to an alpha 2-8 bond, a phosphate, a sulphate, or carboxyl-group or a monosaccharide having a phosphate, sulphate, or carboxyl group and only one of the radicals X is present.

Inventors:
STAHL BERND (DE)
KELM SOERGE (DE)
BOEHM GUENTHER (DE)
FINKE BERNDT (DE)
SLAGHIUS JOERG (DE)
Application Number:
PCT/EP2003/000980
Publication Date:
January 22, 2004
Filing Date:
January 31, 2003
Export Citation:
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Assignee:
NUTRICIA NV (NL)
STAHL BERND (DE)
KELM SOERGE (DE)
BOEHM GUENTHER (DE)
FINKE BERNDT (DE)
SLAGHIUS JOERG (DE)
International Classes:
A23C9/20; A23F3/30; A23L1/09; A23L33/00; A61P37/00; C07H7/027; C07H17/04; (IPC1-7): C07H7/027; C07H17/04; A61K31/702; A61P37/00; A23L1/09
Domestic Patent References:
WO2000046379A12000-08-10
WO1992022301A11992-12-23
Foreign References:
Other References:
SIEBERT H-C ET AL: "MOLECULAR DYNAMICS-DERIVED CONFORMATION AND INTRAMOLECULAR INTERACTION ANALYSIS OF THE N-ACETYL-9-ACETYLNEURAMININ ACID-CONTAINING GANGLIODES GD1A AND NMR-BASED ANALYSIS OF ITS BINDING TO A HUMAN POLYCLONAL IMMUNOGLOBULIN G FRACTION WITH SELECTIVITY FOR O-ACETYLATED SIALIC ACIDS", GLYCOBIOLOGY, IRL PRESS,, GB, vol. 6, no. 6, September 1996 (1996-09-01), pages 561 - 572, XP000960721, ISSN: 0959-6658
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