Title:
SINGLET OXYGEN SCAVENGER, ANTI-SKIN-AGING AGENT, ANTI-WRINKLE AGENT, ANTI-SAGGING AGENT, AGENT FOR IMPROVING MOISTURE CONTENT IN THE SKIN, SKIN-WHITENING AGENT, MELANIN FORMATION INHIBITOR, NITROGEN MONOOXIDE SCAVENGER AND ANTIOXIDANT, EACH UTILIZING HELIPYRONE A
Document Type and Number:
WIPO Patent Application WO/2007/125832
Kind Code:
A1
Abstract:
A new action of Helipyrone A is now found. As a useful application of Helipyrone A,
the following agent is disclosed: a singlet oxygen scavenger, an anti-skin-aging agent,
an anti-wrinkle agent, an anti-sagging agent, an agent for improving the moisture
content in the skin, a skin-whitening agent, a melanin formation inhibitor,
a nitrogen monooxide scavenger or an antioxidant, each comprising Helipyrone
A.
Inventors:
KON TATSUYA (JP)
Application Number:
PCT/JP2007/058643
Publication Date:
November 08, 2007
Filing Date:
April 20, 2007
Export Citation:
Assignee:
FANCL CORP (JP)
KON TATSUYA (JP)
KON TATSUYA (JP)
International Classes:
A61K31/366; A23L1/30; A61K8/49; A61P17/16; A61P17/18; A61P39/06; A61P43/00; A61Q19/00; A61Q19/02; A61Q19/08; C07D309/38; C09K15/06
Foreign References:
| JP2001322932A | 2001-11-20 | |||
| JP2003321463A | 2003-11-11 | |||
| JP2003137789A | 2003-05-14 |
Other References:
ALI E. ET AL.: "Helipyrone from Anaphalis araneosa and its synthesis", PHYTOCHEMISTRY, vol. 21, no. 1, 1982, pages 243 - 244, XP003018874
RIOS J.L. ET AL.: "Isolation and identification of the antibacterial compounds from Helichrysum stoechas", JOURNAL OF ETHNOPHARMACOLOGY, vol. 33, no. 1, 1991, pages 51 - 55, XP003018875
HUA Y. ET AL.: "Chemical components of Anaphalis sinica Hance", JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 51, no. 2, 2004, pages 409 - 415, XP003018876
APPENDINO G. ET AL.: "Arzanol, an Anti-inflammatory and Anti-HIV-1 Phloroglucinol a-Pyrone from Helichrysum italicum ssp. microphyllum", JOURNAL OF NATURAL PRODUCTS, vol. 70, no. 4, 2007, pages 608 - 612, XP003018877
PEYRON L. ET AL.: "Composition of Helichrysum essential oils", INT. CONGR. ESSENT. OILS, vol. 7TH, 1979, pages 421 - 424, XP003018878
LAVAULT M. ET AL.: "Constituents of Helichrysum stoechas variety of olonnense", CHEMISTRY OF NATURAL COMPOUNDS, vol. 40, no. 2, 2004, pages 118 - 121, XP003018879
ROSA A. ET AL.: "Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp. microphyllum", CHEM. BIOL. INTERACT., vol. 30, no. 165, January 2007 (2007-01-01), pages 117 - 126, XP005828630
WEBER V. ET AL.: "Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species", ARZNEIMITTEL-FORSCHUNG, vol. 51, no. 11, 2001, pages 877 - 884, XP003018880
RIOS J.L. ET AL.: "Isolation and identification of the antibacterial compounds from Helichrysum stoechas", JOURNAL OF ETHNOPHARMACOLOGY, vol. 33, no. 1, 1991, pages 51 - 55, XP003018875
HUA Y. ET AL.: "Chemical components of Anaphalis sinica Hance", JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 51, no. 2, 2004, pages 409 - 415, XP003018876
APPENDINO G. ET AL.: "Arzanol, an Anti-inflammatory and Anti-HIV-1 Phloroglucinol a-Pyrone from Helichrysum italicum ssp. microphyllum", JOURNAL OF NATURAL PRODUCTS, vol. 70, no. 4, 2007, pages 608 - 612, XP003018877
PEYRON L. ET AL.: "Composition of Helichrysum essential oils", INT. CONGR. ESSENT. OILS, vol. 7TH, 1979, pages 421 - 424, XP003018878
LAVAULT M. ET AL.: "Constituents of Helichrysum stoechas variety of olonnense", CHEMISTRY OF NATURAL COMPOUNDS, vol. 40, no. 2, 2004, pages 118 - 121, XP003018879
ROSA A. ET AL.: "Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp. microphyllum", CHEM. BIOL. INTERACT., vol. 30, no. 165, January 2007 (2007-01-01), pages 117 - 126, XP005828630
WEBER V. ET AL.: "Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species", ARZNEIMITTEL-FORSCHUNG, vol. 51, no. 11, 2001, pages 877 - 884, XP003018880
Attorney, Agent or Firm:
KODAMA, Yoshihiro et al. (17-2 Sotokanda 2-chom, Chiyoda-ku Tokyo 21, JP)
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