Title:
SIRT1 RECEPTOR AGONIST AND MEDICAMENT COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2021/204193
Kind Code:
A1
Abstract:
The present invention belongs to the field of medicaments or nutraceutical products, and specifically relates to a compound represented by the following general formula (I), or an enantiomer, diastereomer, salt, ester, prodrug, solvate, or solvate of a salt thereof, wherein R1, R2, and R3 are as defined in the specification of the present invention. The compound prepared by the present invention brings about an effect of activating Sirt1, and can be used as a potential Sirt1 agonist. By using a hyperuricemia animal model, the compound of the present invention is found to bring about an effect of significantly lowering the level of uric acid in the body, and can be used as a potential medicament for lowering the level of uric acid or treating gout.
Inventors:
WEN YAOLIN (CN)
SUN JUNZHE (CN)
SHEN KAI (CN)
SUN JUNZHE (CN)
SHEN KAI (CN)
Application Number:
PCT/CN2021/085919
Publication Date:
October 14, 2021
Filing Date:
April 08, 2021
Export Citation:
Assignee:
CATCH BIO SCIENCE & TECH CO LTD (CN)
International Classes:
C07C49/24; A61K31/201; A61K31/215; A61K31/22; A61K31/335; A61K31/7028; A61P19/06; C07C33/048; C07C43/196; C07C49/20; C07C49/255; C07C69/00; C07D303/00
Foreign References:
| CN109893521A | 2019-06-18 | |||
| CN109893517A | 2019-06-18 | |||
| CN109893533A | 2019-06-18 | |||
| CN109893538A | 2019-06-18 | |||
| JPWO2012091115A1 | 2014-06-05 |
Other References:
J.D.BU'LOCK ET AL.: "Polyacetylenic Acid in Developing Seedlings of Sweet Quandong", BIOCHEMICAL JOURNAL, vol. 85, 31 December 1962 (1962-12-31), GB , pages 35, XP009531025, ISSN: 0264-6021
FERDINAND BOHLMANN ET AL.: "Polyacetylene Compounds. X. Synthesis of the Polyynes from Oenanthe Crocata", CHEMISCHE BERICHTE, vol. 88, no. 8, 31 December 1955 (1955-12-31), DE , pages 1245 - 1251, XP009531024, ISSN: 0009-2940
L. CROMBIE, J.C. WILLIAMS: "Lipids. VIII. Syntheses of cis- and trans-Octadec 13-Ene-9, 11-Diynoic Acids, and Octadeca-cis-13, trans-15-and-trans-13, trans-15 -Diene-9, 11-Diynoic Acids: Their Status in Nature", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1962 (1962-12-31), pages 2449 - 2454, XP009531023, ISSN: 0368-1769
HARTMUT LAATSCH, ALKE PUDLEINER: "Synthesis of ω-Acetyl-α-Methylenepolyene Carboxylic Esters", JOURNAL FUER PRAKTISCHE CHEMIE/CHEMIKER-ZEITUNG, vol. 336, no. 8, 31 December 1994 (1994-12-31), pages 663 - 677, XP009531022, ISSN: 0941-1216
SOMMERWERK SVEN, HELLER LUCIE, SIEWERT BIANKA, CSUK RENÉ: "Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues", BIOORGANIC, ELSEVIER, vol. 23, no. 17, 1 September 2015 (2015-09-01), AMSTERDAM, NL, pages 5595 - 5602, XP055856740, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.07.031
FERDINAND BOHLMANN ET AL.: "Polyacetylene Compounds. X. Synthesis of the Polyynes from Oenanthe Crocata", CHEMISCHE BERICHTE, vol. 88, no. 8, 31 December 1955 (1955-12-31), DE , pages 1245 - 1251, XP009531024, ISSN: 0009-2940
L. CROMBIE, J.C. WILLIAMS: "Lipids. VIII. Syntheses of cis- and trans-Octadec 13-Ene-9, 11-Diynoic Acids, and Octadeca-cis-13, trans-15-and-trans-13, trans-15 -Diene-9, 11-Diynoic Acids: Their Status in Nature", JOURNAL OF THE CHEMICAL SOCIETY, 31 December 1962 (1962-12-31), pages 2449 - 2454, XP009531023, ISSN: 0368-1769
HARTMUT LAATSCH, ALKE PUDLEINER: "Synthesis of ω-Acetyl-α-Methylenepolyene Carboxylic Esters", JOURNAL FUER PRAKTISCHE CHEMIE/CHEMIKER-ZEITUNG, vol. 336, no. 8, 31 December 1994 (1994-12-31), pages 663 - 677, XP009531022, ISSN: 0941-1216
SOMMERWERK SVEN, HELLER LUCIE, SIEWERT BIANKA, CSUK RENÉ: "Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues", BIOORGANIC, ELSEVIER, vol. 23, no. 17, 1 September 2015 (2015-09-01), AMSTERDAM, NL, pages 5595 - 5602, XP055856740, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.07.031
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
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