SITE-DIRECTED DUAL PEGYLATION OF PROTEINS

Title:

SITE-DIRECTED DUAL PEGYLATION OF PROTEINS

Document Type and Number:

WIPO Patent Application WO2000021574

Kind Code:

A3

Abstract:

The present invention relates generally to the chemical modification of biologically active agents. More specifically, the invention relates to a novel approach to engineer, through mutagenesis and site-directed chemical conjugation, specific, well-defined dualPEGylated-protein bioconjugates, consisting of two polyethylene glycol (PEG) macromolecules chemically conjugated to the protein at two specifically defined amino acid residues. The described dualPEGylated-protein bioconjugates show substantially improved bioefficacy and biocompatibility.

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Inventors:

GEGG COLIN
KINSTLER OLAF

Application Number:

PCT/US1999/024401

Publication Date:

August 17, 2000

Filing Date:

October 13, 1999

Export Citation:

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Assignee:

AMGEN INC (US)

International Classes:

A61K38/00; C12N15/09; A61K47/48; A61P3/04; A61P3/06; A61P3/10; C07K14/47; (IPC1-7): A61K47/48

Domestic Patent References:

WO1996040912A1	1996-12-19
WO2000009165A1	2000-02-24
WO1998024896A2	1998-06-11

Foreign References:

EP0741187A2	1996-11-06
EP0822199A2	1998-02-04

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