Title:
SITE-SPECIFIC ANTIBODY CONJUGATION AND ANTIBODY-DRUG CONJUGATE AS SPECIFIC EXAMPLE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/184944
Kind Code:
A1
Abstract:
The present application relates to a technology enabling a specific number of chemical functional groups or cargo moieties to be labeled at specific sites of an antibody. An antibody product having high uniformity can be provided by the present application. In addition, an antibody product in which functions of the antibody do not decline can be provided by the present application. That is, an antibody product of which avidity and half-life do not decline can be provided. The present application is very meaningful by being the first technology that enables site-specific labeling of antibodies without a complicated process.
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Inventors:
CHUNG SANG JEON (KR)
KIM JU HWAN (KR)
LEE YOUNG GEUN (KR)
LEE TAE JIN (KR)
SEO JIN WOO (KR)
KIM JU HWAN (KR)
LEE YOUNG GEUN (KR)
LEE TAE JIN (KR)
SEO JIN WOO (KR)
Application Number:
PCT/KR2020/003282
Publication Date:
September 17, 2020
Filing Date:
March 09, 2020
Export Citation:
Assignee:
ABTIS CO LTD (KR)
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
International Classes:
C07D207/46; A61K39/00; A61K47/65; A61K47/68; A61P35/00; C07K7/08; C07K16/28
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| WO2018199337A1 | 2018-11-01 | |||
| WO2018199337A1 | 2018-11-01 | |||
| WO1992019244A2 | 1992-11-12 | |||
| WO1997032572A2 | 1997-09-12 | |||
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HALEMARHAM: "Monoclonal Antibodies, Cytokines and Arthritis", 1991, SPRINGER VERLAG
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"Protein Ligand Design: From Phage Display to Synthetic Protein Epitope Mimetics in Human Antibody Fc-Binding Peptidomimetics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, no. 8, 2006, pages 2726 - 2732
DELANO, W.L. ET AL.: "Convergent solutions to binding at a protein-protein interface", SCIENCE, vol. 287, 2000, pages 1279 - 1283, XP002211313, DOI: 10.1126/science.287.5456.1279
XAI, FORMULAS, vol. 3, pages 3 - 1
YING TJU TWWANG YPRABAKARAN PDIMITROV DS.: "Interactions of IgG1 CH2 and CH3 Domains with FcRn", FRONT IMMUNOL, vol. 5, 2014, pages 146
MONNET CJORIEUX SURBAIN R ET AL.: "Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions", FRONT IMMUNOL, vol. 6, 2015, pages 39
SLAMON ET AL., NEW ENGL. J. MED., vol. 344, 2001, pages 783 - 792
BENIAMINOVITZ ET AL., NEW ENGL. J. MED., vol. 343, 2000, pages 1594 - 1602
"Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases", 1993, MARCEL DEKKER
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
NING ET AL., RADIOTHERAPY & ONCOLOGY, vol. 39, 1996, pages 179 - 189
GHOSH ET AL., NEW ENGL. J. MED., vol. 348, 2003, pages 601 - 608
MILGROM ET AL., NEW ENGL. J. MED., vol. 341, 1999, pages 1966 - 1973
DENT: "Pharmacotherapeutics for Advanced Practice:A Practical Approach", 2001, LIPPINCOTT, WILLIAMS & WILKINS
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
EPSTEIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 3688 - 3692
HWANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4030 - 4034
SEFTON, CRC CRIT. REF BIOMED. ENG., vol. 14, 1987, pages 20
BUCHWALD ET AL., SURGERY, vol. 88, 1980, pages 507
SAUDEK ET AL., N. ENGL. J. MED., vol. 321, 1989, pages 574
"Medical Applications of Controlled Release", 1974, CRC PRES.
GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, vol. 2, 1984, pages 115 - 138
RANGERPEPPAS, J. MACROMOL. SCI. REV. MACROMOL. CHEM., vol. 23, 1983, pages 61
LEVY ET AL., SCIENCE, vol. 228, 1985, pages 190
DURING ET AL., ANN. NEUROL., vol. 25, 1989, pages 351
HOWARD ET AL., J. NEUROSURG., vol. 7 1, 1989, pages 105
SONG ET AL., PDA JOURNAL OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, vol. 50, 1995, pages 372 - 397
CLEEK ET AL., PRO. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., vol. 24, 1997, pages 853 - 854
LAM ET AL., PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., vol. 24, 1997, pages 759 - 760
BLOEMAN ET AL., FEBS LETT, vol. 357, 1995, pages 140
RANADE, J. CLIN. PHARMACOL., vol. 29, 1989, pages 685
OWAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER, vol. 39, 1995, pages 180
BRISCOE ET AL., AM. J. PHYSIOL., vol. 1233, 1995, pages 134
K. KEINANENM. L. LAUKKANEN, FEBS LETT., vol. 346, 1994, pages 123
J. J. KILLIONI. J. FIDLER, IMMUNOMETHODS, vol. 4, 1994, pages 273
See also references of EP 3936501A4
SCHREIER ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 9090
UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1038
HALEMARHAM: "Monoclonal Antibodies, Cytokines and Arthritis", 1991, SPRINGER VERLAG
TORNOE ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 67, 2002, pages 3057 - 3064
"Advanced Organic Chemistry: reactions, mechanisms and structure", 1992, JOHN WILEY AND SONS, pages: 351 - 357
DELANO, W.L.: "Convergent Solutions to Binding at a Protein-Protein Interface", SCIENCE, vol. 287, no. 5456, 2000, pages 1279 - 1283, XP002211313, DOI: 10.1126/science.287.5456.1279
W. LANCE MARTIN ET AL., MOLECULAR CELL, vol. 7, April 2001 (2001-04-01), pages 867 - 877
EDELMAN GM ET AL.: "The covalent structure of an entire gamma-G immunoglobulin molecule", PROC. NATL. ACAD. SCI. USA., vol. 63, no. 1, May 1969 (1969-05-01), pages 78 - 85
"Protein Ligand Design: From Phage Display to Synthetic Protein Epitope Mimetics in Human Antibody Fc-Binding Peptidomimetics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, no. 8, 2006, pages 2726 - 2732
DELANO, W.L. ET AL.: "Convergent solutions to binding at a protein-protein interface", SCIENCE, vol. 287, 2000, pages 1279 - 1283, XP002211313, DOI: 10.1126/science.287.5456.1279
XAI, FORMULAS, vol. 3, pages 3 - 1
YING TJU TWWANG YPRABAKARAN PDIMITROV DS.: "Interactions of IgG1 CH2 and CH3 Domains with FcRn", FRONT IMMUNOL, vol. 5, 2014, pages 146
MONNET CJORIEUX SURBAIN R ET AL.: "Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions", FRONT IMMUNOL, vol. 6, 2015, pages 39
SLAMON ET AL., NEW ENGL. J. MED., vol. 344, 2001, pages 783 - 792
BENIAMINOVITZ ET AL., NEW ENGL. J. MED., vol. 343, 2000, pages 1594 - 1602
"Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases", 1993, MARCEL DEKKER
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
NING ET AL., RADIOTHERAPY & ONCOLOGY, vol. 39, 1996, pages 179 - 189
GHOSH ET AL., NEW ENGL. J. MED., vol. 348, 2003, pages 601 - 608
MILGROM ET AL., NEW ENGL. J. MED., vol. 341, 1999, pages 1966 - 1973
DENT: "Pharmacotherapeutics for Advanced Practice:A Practical Approach", 2001, LIPPINCOTT, WILLIAMS & WILKINS
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
EPSTEIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 3688 - 3692
HWANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4030 - 4034
SEFTON, CRC CRIT. REF BIOMED. ENG., vol. 14, 1987, pages 20
BUCHWALD ET AL., SURGERY, vol. 88, 1980, pages 507
SAUDEK ET AL., N. ENGL. J. MED., vol. 321, 1989, pages 574
"Medical Applications of Controlled Release", 1974, CRC PRES.
GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, vol. 2, 1984, pages 115 - 138
RANGERPEPPAS, J. MACROMOL. SCI. REV. MACROMOL. CHEM., vol. 23, 1983, pages 61
LEVY ET AL., SCIENCE, vol. 228, 1985, pages 190
DURING ET AL., ANN. NEUROL., vol. 25, 1989, pages 351
HOWARD ET AL., J. NEUROSURG., vol. 7 1, 1989, pages 105
SONG ET AL., PDA JOURNAL OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, vol. 50, 1995, pages 372 - 397
CLEEK ET AL., PRO. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., vol. 24, 1997, pages 853 - 854
LAM ET AL., PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., vol. 24, 1997, pages 759 - 760
BLOEMAN ET AL., FEBS LETT, vol. 357, 1995, pages 140
RANADE, J. CLIN. PHARMACOL., vol. 29, 1989, pages 685
OWAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER, vol. 39, 1995, pages 180
BRISCOE ET AL., AM. J. PHYSIOL., vol. 1233, 1995, pages 134
K. KEINANENM. L. LAUKKANEN, FEBS LETT., vol. 346, 1994, pages 123
J. J. KILLIONI. J. FIDLER, IMMUNOMETHODS, vol. 4, 1994, pages 273
See also references of EP 3936501A4
Attorney, Agent or Firm:
IPS PATENT FIRM (KR)
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