Title:
SKIN WHITENING COMPOSITION CONTAINING DIHYDROFURAN-2(3H)-ONE DIMER
Document Type and Number:
WIPO Patent Application WO/2022/080765
Kind Code:
A1
Abstract:
The present invention relates to a skin whitening composition comprising a dihydrofuran-2(3H)-one derivative having melanogenesis inhibition and melanosome decomposition activity, an isomer thereof, or a pharmaceutically acceptable salt thereof. Specifically, the composition of the present invention inhibits melanogenesis and promotes melanosome degradation by means of action of the dihydrofuran-2(3H)-one derivative on a melanin biosynthesis signaling pathway induced by α-MSH (Melanocyte-stimulating hormone).
Inventors:
YUN CHEONGYONG (KR)
Application Number:
PCT/KR2021/013839
Publication Date:
April 21, 2022
Filing Date:
October 08, 2021
Export Citation:
Assignee:
EPI BIOTECH CO LTD (KR)
International Classes:
A61K8/49; A23L33/10; A61K31/365; A61P17/00; A61Q19/02; C07D307/32; C07D307/58; C07D407/06
Foreign References:
| CN102491963A | 2012-06-13 | |||
| KR20090084624A | 2009-08-05 |
Other References:
CASSADY JOHN M, ET AL: "Potential antitumor agents. Synthesis, reactivity, and cytotoxicity of .alpha.-methylene carbonyl compounds", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 8, 1 January 1978 (1978-01-01), US , pages 815 - 819, XP002502138, ISSN: 0022-2623, DOI: 10.1021/jm00206a020
GHARPURE SANTOSH J., NANDA LAXMI NARAYAN, SHUKLA MANOJ KUMAR: "Donor–Acceptor Substituted Cyclopropane to Butanolide and Butenolide Natural Products: Enantiospecific First Total Synthesis of (+)-Hydroxyancepsenolide", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 24, 19 December 2014 (2014-12-19), US , pages 6424 - 6427, XP055920945, ISSN: 1523-7060, DOI: 10.1021/ol503246k
WANG HUI-MIN, CHEN CHUNG-YI, WEN ZHI-HONG: "Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase : Targeting the human tyrosinase", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 20, no. 3, 5 November 2010 (2010-11-05), COPENHAGEN; DK , pages 242 - 248, XP055777764, ISSN: 0906-6705, DOI: 10.1111/j.1600-0625.2010.01161.x
GHARPURE SANTOSH J., NANDA LAXMI NARAYAN, SHUKLA MANOJ KUMAR: "Donor–Acceptor Substituted Cyclopropane to Butanolide and Butenolide Natural Products: Enantiospecific First Total Synthesis of (+)-Hydroxyancepsenolide", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 24, 19 December 2014 (2014-12-19), US , pages 6424 - 6427, XP055920945, ISSN: 1523-7060, DOI: 10.1021/ol503246k
WANG HUI-MIN, CHEN CHUNG-YI, WEN ZHI-HONG: "Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase : Targeting the human tyrosinase", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 20, no. 3, 5 November 2010 (2010-11-05), COPENHAGEN; DK , pages 242 - 248, XP055777764, ISSN: 0906-6705, DOI: 10.1111/j.1600-0625.2010.01161.x
Attorney, Agent or Firm:
CHOI, Eun Sun (KR)
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