Title:
SMALL-MOLECULE COMPOUND HAVING A2A ADENOSINE RECEPTOR ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2020/253867
Kind Code:
A1
Abstract:
The present application provides a small-molecule compound, represented by general formula (I), having A2A adenosine receptor antagonistic activity and a pharmaceutical composition containing same. The compound and composition can be used as A2A adenosine receptor antagonistic agents.
Inventors:
ZHONG WU (CN)
ZHANG MIN (CN)
ZHOU XINBO (CN)
FAN SHIYONG (CN)
LI SONG (CN)
ZHANG MIN (CN)
ZHOU XINBO (CN)
FAN SHIYONG (CN)
LI SONG (CN)
Application Number:
PCT/CN2020/097393
Publication Date:
December 24, 2020
Filing Date:
June 22, 2020
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07H19/167; A61K31/7076; A61P9/10
Foreign References:
| JPH07242694A | 1995-09-19 | |||
| JPH07242694A | 1995-09-19 | |||
| CN201910542437A | 2019-06-21 | |||
| CN201180022061A | 2011-03-29 |
Other References:
CHEN, HUIJUN ET AL.: "Novel Synthesis of 7-β-D-Ribofuranosyl-7H-1,2,4-triazolo[3,4-i]purines with Use of NBS", SYNTHETIC COMMUNICATIONS, vol. 36, no. 4, 31 December 2006 (2006-12-31), XP055767116, ISSN: 0039-7911, DOI: 20200910155838X
FREDHOLM B B ET AL., PHARMACOL REV, vol. 63, 2011, pages 1 - 34
FREDHOLM BB ET AL., EXP CELL RES, vol. 316, 2010, pages 1284 - 8
DE LERA RUIZ M ET AL., J MED CHEM, vol. 57, 2014, pages 3623 - 50
CHEN J F ET AL., NAT REV DRUG DISCOV, vol. 12, 2013, pages 265 - 86
MULLER C E ET AL., BIOCHIM BIOPHYS ACTA, vol. 1808, 2011, pages 1290 - 308
YUAN G ET AL., CURR MED CHEM, vol. 21, 2014, pages 3918 - 35
LAPPAS C M ET AL., EXPERT OPIN INVESTIG DRUGS, vol. 14, 2005, pages 797 - 806
VARANI K ET AL., AUTOIMMUN REV, vol. 10, 2010, pages 61 - 4
CRISTALLI G ET AL., CHEMMEDCHEM, vol. 2, 2007, pages 260 - 81
CACCIARI B ET AL., CURR TOP MED CHEM, vol. 3, 2003, pages 403 - 11
MORO S ET AL., MED RES REV, vol. 26, 2006, pages 131 - 59
SCHWARZSCHILD MA ET AL., TRENDS NEUROSCI, vol. 29, 2006, pages 647 - 54
SCHAPIRA AH ET AL., NAT REV DRUG DISCOV, vol. 5, 2006, pages 845 - 54
IMPAGNATIELLO F ET AL., EMERG THER TARGETS, vol. 4, 2000, pages 635 - 63
FUXE K ET AL., MOV DISORD, vol. 22, 2007, pages 1990 - 2017
XU K ET AL., PHARMACOL THER, vol. 105, 2005, pages 267 - 310
MELANI A ET AL., BRAIN RES, vol. 1073-1074, 2006, pages 470 - 80
MONOPOLI A ET AL., NEUROREPORT, vol. 9, 1998, pages 3955 - 9
RICHARDSON PJ ET AL., TRENDS PHARMACOL SCI, vol. 18, 1997, pages 338 - 44
PEDATA F ET AL., NEUROL RES, vol. 27, 2005, pages 169 - 74
LEDENT C ET AL., NATURE, vol. 388, 1997, pages 674 - 8
THORSELL A ET AL., ALCOHOL CLIN EXP RES, vol. 31, 2007, pages 1302 - 7
BRAMBILLA R ET AL., GLIA, vol. 43, 2003, pages 190 - 4
TAKAHASHI RN ET AL., FRONT BIOSCI, vol. 13, 2008, pages 2614 - 32
YANG M ET AL., NAUNYN SCHMIEDEBERG'S ARCH PHARMACOL, vol. 375, 2007, pages 133 - 44
YUZLENKO O ET AL., CURR MED CHEM, vol. 13, 2006, pages 3609 - 25
See also references of EP 3988560A4
FREDHOLM B B ET AL., PHARMACOL REV, vol. 63, 2011, pages 1 - 34
FREDHOLM BB ET AL., EXP CELL RES, vol. 316, 2010, pages 1284 - 8
DE LERA RUIZ M ET AL., J MED CHEM, vol. 57, 2014, pages 3623 - 50
CHEN J F ET AL., NAT REV DRUG DISCOV, vol. 12, 2013, pages 265 - 86
MULLER C E ET AL., BIOCHIM BIOPHYS ACTA, vol. 1808, 2011, pages 1290 - 308
YUAN G ET AL., CURR MED CHEM, vol. 21, 2014, pages 3918 - 35
LAPPAS C M ET AL., EXPERT OPIN INVESTIG DRUGS, vol. 14, 2005, pages 797 - 806
VARANI K ET AL., AUTOIMMUN REV, vol. 10, 2010, pages 61 - 4
CRISTALLI G ET AL., CHEMMEDCHEM, vol. 2, 2007, pages 260 - 81
CACCIARI B ET AL., CURR TOP MED CHEM, vol. 3, 2003, pages 403 - 11
MORO S ET AL., MED RES REV, vol. 26, 2006, pages 131 - 59
SCHWARZSCHILD MA ET AL., TRENDS NEUROSCI, vol. 29, 2006, pages 647 - 54
SCHAPIRA AH ET AL., NAT REV DRUG DISCOV, vol. 5, 2006, pages 845 - 54
IMPAGNATIELLO F ET AL., EMERG THER TARGETS, vol. 4, 2000, pages 635 - 63
FUXE K ET AL., MOV DISORD, vol. 22, 2007, pages 1990 - 2017
XU K ET AL., PHARMACOL THER, vol. 105, 2005, pages 267 - 310
MELANI A ET AL., BRAIN RES, vol. 1073-1074, 2006, pages 470 - 80
MONOPOLI A ET AL., NEUROREPORT, vol. 9, 1998, pages 3955 - 9
RICHARDSON PJ ET AL., TRENDS PHARMACOL SCI, vol. 18, 1997, pages 338 - 44
PEDATA F ET AL., NEUROL RES, vol. 27, 2005, pages 169 - 74
LEDENT C ET AL., NATURE, vol. 388, 1997, pages 674 - 8
THORSELL A ET AL., ALCOHOL CLIN EXP RES, vol. 31, 2007, pages 1302 - 7
BRAMBILLA R ET AL., GLIA, vol. 43, 2003, pages 190 - 4
TAKAHASHI RN ET AL., FRONT BIOSCI, vol. 13, 2008, pages 2614 - 32
YANG M ET AL., NAUNYN SCHMIEDEBERG'S ARCH PHARMACOL, vol. 375, 2007, pages 133 - 44
YUZLENKO O ET AL., CURR MED CHEM, vol. 13, 2006, pages 3609 - 25
See also references of EP 3988560A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF: