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Patent Searching and Data


Title:
SMALL MOLECULE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/078020
Kind Code:
A1
Abstract:
The present invention provides a small molecule compound, having a structure represented by the following molecular general formula (I), wherein X1 and X2 are selected from carbon or nitrogen; one or more carbons in A1, A2, A3, A4, and A5 are substituted by nitrogen, sulphur or oxygen; a five-membered ring formed by A1, A2, A3, A4, and A5 has aromatic properties; any one or several hydrogen atoms on the five-membered ring are substituted by R; R is selected from a group consisting of hydrogen, halogen, alkyl, substituted alkyl, amino, substituted amino, carboxyl, acylamino, substituted acylamino, substituted carbonyl, ester group, substituted ester group, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl. The small molecule compound of the present invention can serve as an efficient and specific Jak kinase inhibitor, particularly, a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a Tyk2/JAK1 dual inhibitor, and/or a Tyk2/JAK2 dual inhibitor.

Inventors:
XING LI (CN)
LI GUAN QUN (CN)
WANG XIAO LEI (CN)
CAI YU TING (CN)
JIANG XIANG (CN)
PAN XIANG (CN)
ZHU WEN HAO (CN)
WANG YANG (CN)
WANG ZENG QUAN (CN)
Application Number:
PCT/CN2020/120130
Publication Date:
April 29, 2021
Filing Date:
October 10, 2020
Export Citation:
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Assignee:
TECHNODERMA MEDICINES PTE LTD (CN)
International Classes:
C07D403/14; A61P19/02; A61P29/00; A61P37/02; C07D401/14; C07D405/14
Domestic Patent References:
WO2016014542A12016-01-28
WO2007053776A12007-05-10
Foreign References:
CN110734428A2020-01-31
CN110862380A2020-03-06
CN110862380A2020-03-06
CN110627775A2019-12-31
CN103298794A2013-09-11
CN110191884A2019-08-30
Other References:
DATABASE REGISTRY 29 July 2020 (2020-07-29), ANONYMOUS: "- /1 -(C) FILE REGISTRY RN -2451205-81-3 REGISTRY ED -Entered STN: 29 Jul 2020 CN -2-Pyrimidinamine, N-(1-methyl-1H-pyrazol-4-yl)-4-[1-(4-piperidinyl)-1H- pyrazol-4-yl]-(CA INDEX NAME", XP055805660, Database accession no. 2451205-81-3
Attorney, Agent or Firm:
SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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