Title:
SMALL MOLECULE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/078023
Kind Code:
A1
Abstract:
Provided is a small molecule compound, which is characterized in having the structure represented by the following molecular formula: (I), wherein X1 and X2 are selected from carbon or nitrogen; G1 is a carbocyclic ring or heterocyclic ring having aromaticity; any one or several hydrogen atoms on the ring of G1 are substituted by R1; and R1 is selected from nitrogen-containing groups. The small molecule compound of the present invention can be used as a highly effective and specific JAK kinase inhibitor, especially a Tyk2 inhibitor, and/or a JAK1 inhibitor, and/or a JAK1/Tyk2 or Tyk2/JAK1, Tyk2/Jak2 dual inhibitor.
Inventors:
XING LI (CN)
LI GUANQUN (CN)
WANG XIAOLEI (CN)
CAI YUTING (CN)
JIANG XIANG (CN)
PAN XIANG (CN)
ZHU WENHAO (CN)
WANG YANG (CN)
WANG ZENGQUAN (CN)
LI GUANQUN (CN)
WANG XIAOLEI (CN)
CAI YUTING (CN)
JIANG XIANG (CN)
PAN XIANG (CN)
ZHU WENHAO (CN)
WANG YANG (CN)
WANG ZENGQUAN (CN)
Application Number:
PCT/CN2020/120134
Publication Date:
April 29, 2021
Filing Date:
October 10, 2020
Export Citation:
Assignee:
TECHNODERMA MEDICINES PTE LTD (CN)
International Classes:
C07D403/14; A61P1/04; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P37/02; C07D401/14; C07D403/12; C07D405/14
Domestic Patent References:
| WO2019222101A1 | 2019-11-21 | |||
| WO2020118683A1 | 2020-06-18 | |||
| WO2016201271A1 | 2016-12-15 | |||
| WO2016201280A1 | 2016-12-15 |
Foreign References:
| CN110627775A | 2019-12-31 | |||
| CN110862380A | 2020-03-06 | |||
| CN110330484A | 2019-10-15 | |||
| CN102459264A | 2012-05-16 | |||
| CN102459265A | 2012-05-16 | |||
| CN106459002A | 2017-02-22 | |||
| CN103298794A | 2013-09-11 | |||
| CN105848723A | 2016-08-10 | |||
| CN105980387A | 2016-09-28 |
Other References:
SHU LEI ET AL.: "Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 191, 16 February 2020 (2020-02-16), XP086086427, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112148
LI CHAOMIN, FRANKLIN LLOYD, CHEN ROBBIE, MACK TAMERA, HUMORA MICHAEL, MA BIN, HOPKINS BRIAN T., GUZOWSKI JOHN, ZHENG FENGMEI, MACP: "Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 6, 19 June 2020 (2020-06-19), US, pages 1199 - 1206, XP055805843, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.0c00087
See also references of EP 4050009A4
LI CHAOMIN, FRANKLIN LLOYD, CHEN ROBBIE, MACK TAMERA, HUMORA MICHAEL, MA BIN, HOPKINS BRIAN T., GUZOWSKI JOHN, ZHENG FENGMEI, MACP: "Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 6, 19 June 2020 (2020-06-19), US, pages 1199 - 1206, XP055805843, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.0c00087
See also references of EP 4050009A4
Attorney, Agent or Firm:
SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO.LTD (CN)
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