Title:
SMALL MOLECULE PD-1/PD-L1 INHIBITOR AND USE THEREOF IN DRUGS
Document Type and Number:
WIPO Patent Application WO/2019/174533
Kind Code:
A1
Abstract:
A small molecule PD-1/PD-L1 inhibitor and the use thereof in drugs. Specifically, provided is a small molecule PD-1/PD-L1 inhibitor that is a chemical compound represented by formula (I), or a stereoisomer, geometric isomer, tautomer, oxynitride, hydrate, solvate, metabolic product, ester, pharmaceutically acceptable salt, or prodrug thereof. Further provided is a preparation method for the compound represented by formula (I), a pharmaceutical composition, and the use thereof in preparation of drugs for prevention or treatment of diseases relating to PD-1/PD-L1 signaling pathways.
Inventors:
LIU BING (CN)
YANG TIPING (CN)
YU XINGLONG (CN)
SUN DANDAN (CN)
ZHANG YINGJUN (CN)
YANG TIPING (CN)
YU XINGLONG (CN)
SUN DANDAN (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2019/077582
Publication Date:
September 19, 2019
Filing Date:
March 11, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D403/12; A61K31/4427; A61P35/00; A61P37/00; C07D207/12; C07D213/71; C07D213/85; C07D401/12; C07D401/14; C07D455/02
Domestic Patent References:
| WO2017066227A1 | 2017-04-20 | |||
| WO2015034820A1 | 2015-03-12 | |||
| WO2015160641A2 | 2015-10-22 |
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