Title:
SMALL MOLECULE THERAPEUTIC COMPOUNDS THAT REDUCE THE INCIDENCE OF INTRACEREBRAL HEMORRHAGE AND BRAIN MICROHEMORRHAGES
Document Type and Number:
WIPO Patent Application WO/2018/025083
Kind Code:
A8
Abstract:
The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages, wherein said small molecule therapeutic compounds are selected from the group consisting of artemether and derivatives thereof (such as dihydroartemisinin, artemisinin, artesunate), benidipine, lacidipine, ethynylestradiol and triptolide.
Inventors:
WEN XIAO-YAN (CA)
MACDONALD R (US)
BAKER ANDREW (CA)
SCHWEIZER TOM (CA)
MACDONALD R (US)
BAKER ANDREW (CA)
SCHWEIZER TOM (CA)
Application Number:
PCT/IB2017/001100
Publication Date:
February 28, 2019
Filing Date:
August 02, 2017
Export Citation:
Assignee:
UNITY HEALTH TORONTO (CA)
International Classes:
A61K31/58; A61K31/357; A61K31/366; A61K31/4422; A61K31/4545; A61K31/567; A61P9/00; A61P9/14; C07D211/90; C07D401/12; C07D493/18; C07J1/00; C07J73/00
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