Title:
SMART PEPTIDES AND TRANSFORMABLE NANOPARTICLES FOR CANCER IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2021/030743
Kind Code:
A3
Abstract:
The present invention provides a compound of formula (I): A-B-C (I), wherein A is a hydrophobic moiety; B is a peptide, wherein the peptide forms a beta-sheet; and C is a hydrophilic targeting ligand, wherein the hydrophilic targeting ligand is a LLP2A prodrug, LLP2A, LXY30, LXW64, DUPA, folate, a LHRH peptide, a HER2 ligand, an EGFR ligand, or a toll-like receptor agonist CpG oligonucleotides. The present invention also provides nanocarriers comprising compounds of the present invention, nanofibril formation from the nanocarriers, and methods of using the nanocarriers for treating diseases and imaging.
Inventors:
LAM KIT S (US)
ZHANG LU (US)
ZHANG LU (US)
Application Number:
PCT/US2020/046495
Publication Date:
March 25, 2021
Filing Date:
August 14, 2020
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
A61K47/62; A61K49/00; A61K51/00; A61P35/00
Foreign References:
| US9579400B2 | 2017-02-28 |
Other References:
THOMAS ET AL.: "Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates", BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 5785 - 5788, XP025562046, DOI: 10.1016/j.bmcl.2008.09.078
WANG ET AL.: "Peptide-drug conjugates as effective prodrug strategies for targeted delivery", ADVANCED DRUG DELIVERY REVIEWS, vol. 110, no. 111, 2017, pages 112 - 126, XP085062902, DOI: 10.1016/j.addr.2016.06.015
LUO YAN, WU HAO, FENG CAIHONG, XIAO KAI, YANG XIXIAO, LIU QIANGQIANG, LIN TZU-YIN, ZHANG HONGYONG, WALTON JEFFREY H., AJENA YOUSIF: ""One-Pot" Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)- porphyrin-based Nanotheranostics", THERANOSTICS, vol. 7, no. 16, 2017, pages 3901 - 3914, XP055805389, DOI: 10.7150/thno.20190
LI SHUKUN, XING RUIRUI, CHANG RUI, ZOU QIANLI, YAN XUEHAI: "Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy", CURRENT OPINION IN COLLOID AND INTERFACE SCIENCE, vol. 35, May 2018 (2018-05-01), pages 17 - 25, XP055805394, DOI: 10.1016/j.cocis.2017.12.004
WANG ET AL.: "Peptide-drug conjugates as effective prodrug strategies for targeted delivery", ADVANCED DRUG DELIVERY REVIEWS, vol. 110, no. 111, 2017, pages 112 - 126, XP085062902, DOI: 10.1016/j.addr.2016.06.015
LUO YAN, WU HAO, FENG CAIHONG, XIAO KAI, YANG XIXIAO, LIU QIANGQIANG, LIN TZU-YIN, ZHANG HONGYONG, WALTON JEFFREY H., AJENA YOUSIF: ""One-Pot" Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)- porphyrin-based Nanotheranostics", THERANOSTICS, vol. 7, no. 16, 2017, pages 3901 - 3914, XP055805389, DOI: 10.7150/thno.20190
LI SHUKUN, XING RUIRUI, CHANG RUI, ZOU QIANLI, YAN XUEHAI: "Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy", CURRENT OPINION IN COLLOID AND INTERFACE SCIENCE, vol. 35, May 2018 (2018-05-01), pages 17 - 25, XP055805394, DOI: 10.1016/j.cocis.2017.12.004
Attorney, Agent or Firm:
HOONG, Christina et al. (US)
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