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Title:
SPECIFIC ISOTYPE ANTIBODIES OF SECRETION-EXCRETION ANTI-ANTIGENS OF LEISHMANIA SP OF PROMASTIGOTE OR AMASTIGOTE FORMS USED AS PROTECTION, RESISTANCE AND CURING MARKERS OF MAMMALS TO LEISHMANIASES AND TO INTRACELLULAR PATHOGENIC MICRO-ORGANISM INFECTIONS, AND AS IMMUNOTHERAPEUTIC EFFECTORS
Document Type and Number:
WIPO Patent Application WO2004011500
Kind Code:
A3
Abstract:
The invention concerns immunoglobulins characterized in that they consist in immunoglobulins of IgG2 classes and corresponding sub-classes, specific of secretion-excretion antigens of the prosmatigote and asmatigote forms of Leishmania sp, capable of lyzing Leishmania sp amastigotes and promastigotes in vitro, and neutralizing their proliferation.

Inventors:
PAPIEROK GERARD (FR)
VICENS SERGE (FR)
LEMESRE JEAN-LOUP (FR)
Application Number:
PCT/FR2003/002358
Publication Date:
March 25, 2004
Filing Date:
July 25, 2003
Export Citation:
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Assignee:
BIO VETO TESTS BVT SARL (FR)
PAPIEROK GERARD (FR)
VICENS SERGE (FR)
LEMESRE JEAN-LOUP (FR)
International Classes:
C07K16/20; (IPC1-7): C07K16/20; A61K39/008
Foreign References:
EP0301961A11989-02-01
Other References:
DEPLAZES P ET AL: "Specific IgG1 and IgG2 antibody responses of dogs to Leishmania infantum and other parasites.", PARASITE IMMUNOLOGY. ENGLAND SEP 1995, vol. 17, no. 9, September 1995 (1995-09-01), pages 451 - 458, XP008018879, ISSN: 0141-9838
JIMÉNEZ-RUIZ A ET AL: "Cloning, sequencing, and expression of the PSA genes from Leishmania infantum.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY 15 JAN 1998, vol. 251, no. 1-2, 15 January 1998 (1998-01-15), pages 389 - 397, XP001159173, ISSN: 0014-2956
KEMP M ET AL: "The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major.", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. NETHERLANDS MAR 1998, vol. 20, no. 3, March 1998 (1998-03-01), pages 209 - 218, XP002245424, ISSN: 0928-8244
CIBRELUS P ET AL: "Secreted antigens of the amastigote and promastigote forms of Leishmania infantum inducing a humoral response in humans and dogs.", PARASITE (PARIS, FRANCE) FRANCE JUN 1999, vol. 6, no. 2, June 1999 (1999-06-01), pages 121 - 129, XP008007414, ISSN: 1252-607X
RIERA C ET AL: "Serological and parasitological follow-up in dogs experimentally infected with Leishmania infantum and treated with meglumine antimoniate.", VETERINARY PARASITOLOGY. NETHERLANDS JUL 1999, vol. 84, no. 1-2, July 1999 (1999-07-01), pages 33 - 47, XP002245423, ISSN: 0304-4017
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