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Patent Searching and Data


Title:
SPECIFICALLY-SHAPED CRYSTAL OF COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2020/040233
Kind Code:
A1
Abstract:
The present invention provides a method for obtaining a specifically-shaped crystal (specifically, spherocrystal) of a compound with good reproducibility. This method for producing a specifically-shaped crystal (specifically spherocrystal) of a compound comprises: (1) a step for preparing a supersaturated solution of a compound having a degree of supersaturation equal to or higher than a critical degree of supersaturation; and (2) a step for precipitating a specifically-shaped crystal (specifically spherocrystal) of a compound from the supersaturated solution.

Inventors:
SUKEGAWA JUNPEI (JP)
ARAKI DAIGO (JP)
SUZUKI SHUNPEI (JP)
MINAMI MASAKI (JP)
ONAI TAKUMA (JP)
WAKITA FUMIHIRO (JP)
LIU CHAO (JP)
NAKAMURA EIICHI (JP)
HARANO KOJI (JP)
Application Number:
PCT/JP2019/032722
Publication Date:
February 27, 2020
Filing Date:
August 21, 2019
Export Citation:
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Assignee:
TOWA PHARMACEUTICAL CO LTD (JP)
UNIV TOKYO (JP)
International Classes:
C30B29/54; C07D333/20; C07D401/12; C07D409/04; C07D495/04; C07H1/06; C07H17/00; C07H17/08; C30B7/08; C30B29/60; A61K31/198; A61K31/381; A61K31/4365; A61K31/4439; A61K31/4535; A61K31/7048; A61K31/7052; A61K33/24
Foreign References:
CN104817571A2015-08-05
US20030059837A12003-03-27
US20110009637A12011-01-13
JPS58143832A1983-08-26
Other References:
MINGYANG CHEN, SHICHAO DU, TENG ZHANG, QI WANG, SONGGU WU, JUNBO GONG: "Spherical Crystallization and the Mechanism of Clopidogrel Hydrogen Sulfate", CHEMICAL ENGINEERING TECHNOLOGY, vol. 41, no. 6, 20 April 2018 (2018-04-20), pages 1259 - 1265, XP055688195, ISSN: 0930-7516, DOI: 10.1002/ceat.201700661
ARITA TOSHIHIKO: "Significant improvement in dissolution rate of poorly water-soluble drugs due to additive-free nanoparticles, and supersaturated dissolution", LECTURE PREPRINTS OF THE CHEMICAL SOCIETY OF JAPAN, vol. 93, no. 3, 8 March 2013 (2013-03-08), pages 707
ICHIRO SUNAGAWA: "Crystals: Growth, Morphology and Perfection", 2003, KYORITSU SHUPPAN CO., LTD., pages: 47 - 48
L. GRANASY ET AL., NATURE MATERIALS, vol. 3, 2004, pages 645 - 650
ROBERTO TODESCHINIVIVIANA CONSONNI: "Molecular Descriptors for Chemoinformatics", 2009, WILEY-VCH VERLAG GMBH & CO. KGAA.
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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